Recent publications

Boks MA, Zwaginga JJ, van Ham SM, ten Brinke A. An optimized CFSE-based T-cell suppression assay to evaluate the suppressive capacity of regulatory T-cells induced by human tolerogenic dendritic cells. Scand J Immunol 2010; 72(2):158-168. abstract

Diepenhorst GM, van Ruler O, Besselink MG, van Santvoort HC, Wijnandts PR, Renooij W, Gouma DJ, Gooszen HG, Boermeester MA. Influence of prophylactic probiotics and selective decontaminaton on bacterial translocation in patients undergoing pancreatic surgery: A randomized controlled trial. Shock 2010; :epub Jun 22. abstract

van der Windt GJ, Schouten M, Zeerleder S, Florquin S, van der Poll T. CD44 is Protective During Hyperoxia-induced Lung Injury. Am J Respir Cell Mol Biol 2010; :epub ahead of print. abstract

ten Brinke A, van Schijndel G, Visser R, de Gruijl TD, Zwaginga JJ, van Ham SM. Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8(+) cytotoxic T cells with high cytolytic potential. Cancer Immunol Immunother 2010; :epub ahead of print. abstract

Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedren S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM. PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy. Arthritis Rheum 2010; :epub ahead of print. abstract

Rispens T, den Bleker TH, Aalberse RC. Hybrid IgG4/IgG4 Fc antibodies form upon ′Fab-arm′ exchange as demonstrated by SDS-PAGE or size-exclusion chromatography. Mol Immunol 2010; :epub ahead of print. abstract

Rispens T, Himly M, Ooievaar-De Heer PO, Bleker TH, Aalberse RC. Traces of pFc′ in IVIG interact with human IgG Fc domains and counteract aggregation. Eur J Pharm Sci 2010; 40(1):62-68. abstract

Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B. Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1. J Immunol 2010; 184(5):2686-2692. abstract

van Kuijk AW, de Groot M, Stapel SO, Dijkmans BA, Wolbink GJ, Tak PP. Relationship between the clinical response to adalimumab treatment and serum levels of adalimumab and anti-adalimumab antibodies in patients with psoriatic arthritis. Ann Rheum Dis 2010; 69(3):624-625. abstract

Zwart B. Processing of apoptotic cells in health and systemic autoimmune disease. Amsterdam, University of Amsterdam, March 30, 2010; abstract

Jobsis JJ, Fijnvandraat K, Stapel SO, Bouts AH. Anti-epoetin-antibody-induced anemia in a child with chronic renal failure. Pediatr Nephrol 2010; 25(5):993-994. abstract

Jobsis JJ, Fijnvandraat K, Stapel SO, Bouts AH. Anti-epoetin-antibody-induced anemia in a child with chronic renal failure. Pediatr Nephrol 2010; 25 (5):993-994. abstract

Lecluse LL, Driessen RJ, Spuls PI, de Jong EM, Stapel SO, van Doorn MB, Bos JD, Wolbink GJ. Extent and clinical consequences of antibody formation against adalimumab in patients with plaque psoriasis. Arch Dermatol 2010; 146(2):127-132. abstract

Krop EJ, van de Pol MA, Lutter R, Heederik DJ, Aalberse RC, van der Zee JS. Dynamics in cytokine responses during the development of occupational sensitization to rats. Allergy 2010; :epub ahead of print. abstract

van Baarsen LG, Bos WH, Rustenburg F, van der Pouw Kraan TC, Wolbink GJ, Dijkmans BA, van Schaardenburg D, Verweij CL. Gene expression profiling in autoantibody positive arthralgia patients predicts development of arthritis. Arthritis Rheum 2010; 62(3):694-704. abstract

Ter Weeme M, Vonk AB, Kupreishvili K, van Ham M, Zeerleder S, Wouters D, Stooker W, Eijsman L, van Hinsbergh VW, Krijnen PA, Niessen HW. Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation. Eur J Clin Invest 2010; 40(1):4-10. abstract

Tran L, Baars JW, Aarden L, Beijnen JH, Huitema AD. Pharmacokinetics of rituximab in patients with CD20 positive B-cell malignancies. Hum Antibodies 2010; 19(1):7-13. abstract

van Luijn MM, Chamuleau ME, Thompson JA, Ostrand-Rosenberg S, Westers TM, Souwer Y, Ossenkoppele GJ, van Ham SM, van de Loosdrecht AA. CLIP down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T cell responses. Haematologica 2010; 95(3):485-493. abstract

de Vries MK, Brouwer E, van der Horst-Bruinsma IE, Spoorenberg A, Van Denderen JC, Jamnitski A, Nurmohamed MT, Dijkmans BA, Aarden LA, Wolbink GJ. Decreased clinical response to adalimumab in ankylosing spondylitis is associated with antibody formation. Ann Rheum Dis 2009; 68(11):1787-1788. abstract

Souwer Y. MHC class II antigen presentation by B cells in health and disease. University of Leiden, Leiden, December 1, 2009;

Torres de Heens GL, Kikkert R, Aarden LA, van der Velden U, Loos BG. Effects of smoking on the ex vivo cytokine production in periodontitis. J Periodontal Res 2009; 44 (1):28-34. abstract

Ter Weeme M, Vonk AB, Kupreishvili K, van Ham M, Zeerleeder S, Wouters D, Stooker W, Eijsman L, van Hinsbergh VW, Krijnen PA, Niessen HW. Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation. Eur J Clin Invest 2009; 40(1):4-10. abstract

Ter Weeme M, Vonk AB, Kupreishvili K, van Ham M, Zeerleeder S, Wouters D, Stooker W, Eijsman L, van Hinsbergh VW, Krijnen PA, Niessen HW. Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation. Eur J Clin Invest 2009; 40 (1):4-10. abstract

Kikkert RB. Toll-like Receptors : Tools, Assays, and Implications for in vitro Pyrogen Tests. University of Amsterdam, Amsterdam, September 29, 2009;

Damoiseaux J, Tervaert JW, Derksen R, Hamann D, Hooijkaas H, Klasen I, Kallenberg C, Limburg P, Smeenk R. Autoantibody standardization in The Netherlands. Ann N Y Acad Sci 2009; 1173:10-14. abstract

Chapman MD, Pomes A, Aalberse RC. Molecular Biology of Allergens : Structure and Immune Recognition. Allergy Frontiers : Epignetics, Allergens and Risk Factors 2009; :265-289.

Kikkert RB. Toll-like Receptors : Tools, Assays, and Implications for in vitro Pyrogen Tests. University of Amsterdam, Amsterdam, September 29, 2009;

Labrijn AF, Buijsse AO, van den Bremer ET, Verwilligen AY, Bleeker WK, Thorpe SJ, Killestein J, Polman CH, Aalberse RC, Schuurman J, van de Winkel JG, Parren PW. Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Nat Biotechnol 2009; 27(8):767-771. abstract

Souwer Y. MHC class II antigen presentation by B cells in health and disease. University of Leiden, Leiden, December 1, 2009;

van den Bemt BJ, Vos K, den Broeder AA, Blom M, Thurlings RM, Bartelds GM, Stapel SO, Barrera P, Tak PP, Nurmohamed MT, Wolbink GJ. A single course of rituximab does not abrogate anti-infliximab antibodies in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 68(8):1368-1369. abstract

Pinelli E, Willers SM, Hoek D, Smit HA, Kortbeek LM, Hoekstra M, de Jongste J, van Knapen F, Postma D, Kerkhof M, Aalberse R, van der Giessen JW, Brunekreef B. Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in the Netherlands: the PIAMA birth cohort study. Eur J Clin Microbiol Infec Dis 2009; 28(11):1327-1334. abstract

Pinelli E, Willers SM, Hoek D, Smit HA, Kortbeek LM, Hoekstra M, de Jongste J, van Knapen F, Postma D, Kerkhof M, Aalberse R, van der Giessen JW, Brunekreef B. Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in the Netherlands: the PIAMA birth cohort study. Eur J Clin Microbiol Infec Dis 2009; 28 (11):1327-1334. abstract

Thurlings RM, Teng O, Vos K, Gerlag DM, Aarden L, Stapel SO, van Laar JM, Tak PP, Wolbink GJ. Clinical response, pharmacokinetics, development of human anti-chimeric antibodies, and synovial tissue response to rituximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 69(2):409-412. abstract

Thurlings RM, Teng O, Vos K, Gerlag DM, Aarden L, Stapel SO, van Laar JM, Tak PP, Wolbink GJ. Clinical response, pharmacokinetics, development of human anti-chimeric antibodies, and synovial tissue response to rituximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 69 (2):409-412. abstract

Bartelds GM, Wijbrandts CA, Nurmohamed MT, Stapel SO, Lems WF, Aarden L, Dijkmans BA, Tak PP, Wolbink GJ. Anti-infliximab and anti-adalimumab antibodies in relation to response to adalimumab in infliximab switchers and anti-TNF naive patients: a cohort study. Ann Rheum Dis 2009; :epub ahead of print. abstract

Bartelds GM, Wijbrandts CA, Nurmohamed MT, Stapel SO, Lems WF, Aarden L, Dijkmans BA, Tak PP, Wolbink GJ. Anti-infliximab and anti-adalimumab antibodies in relation to response to adalimumab in infliximab switchers and anti-TNF naive patients: a cohort study. Ann Rheum Dis 2009; :epub. abstract

Scholtens S, Wijga AH, Brunekreef B, Kerkhof M, Hoekstra MO, Gerritsen J, Aalberse R, de Jongste JC, Smit HA. Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. Thorax 2009; 64(7):604-609. abstract

Souwer Y, Griekspoor A, Jorritsma T, de Wit J, Janssen H, Neefjes J, van Ham SM. B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production. J Immunol 2009; 182(12):7473-7481. abstract

Murray-Rust TA, Kerr FK, Thomas AR, Wu T, Tang Y, Ong PC, Quinsey NS, Whisstock JC, Wagenaar-Bos IG, Freeman C, Pike RN. Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1. Biochem J 2009; 422(2):295-303. abstract

Murray-Rust TA, Kerr FK, Thomas AR, Wu T, Tang Y, Ong PC, Quinsey NS, Whisstock JC, Wagenaar-Bos IG, Freeman C, Pike RN. Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1. Biochem J 2009; 422 (2):295-303. abstract

Diepenhorst GM, van Gulik TM, Hack CE. Complement-Mediated Ischemia-Reperfusion Injury: Lessons Learnt From Animal and Clinical Studies. Ann Surg 2009; 249(6):889-899. abstract

Damen CW, de Groot ER, Heij M, Boss DS, Schellens JH, Rosing H, Beijnen JH, Aarden LA. Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma. Anal Biochem 2009; 391(2):114-120. abstract

Wolbink GJ, Aarden LA, Dijkmans BA. Dealing with immunogenicity of biologicals: assessment and clinical relevance. Curr Opin Rheumatol 2009; 21(3):211-215. abstract

Bos WH, Wolbink GJ, Boers M, Tijhuis GJ, de Vries N, van der Horst-Bruinsma IE, Tak PP, van de Stadt R, van der Laken CJ, Dijkmans BA, van Schaardenburg D. Arthritis development in arthralgia patients is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study. Ann Rheum Dis 2010; 69(3):490-494. abstract

Bos WH, Bartelds GM, Vis M, van der Horst AR, Wolbink GJ, van de Stadt RJ, van Schaardenburg D, Dijkmans BA, Lems WF, Nurmohamed MT, Aarden L, Hamann D. Preferential decrease in IgG4 anti-citrullinated protein antibodies during treatment with tumour necrosis factor blocking agents in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 68(4):558-563. abstract

Rispens T, Ooievaar-De Heer P, Vermeulen E, Schuurman J, Neut Kolfschoten M, Aalberse RC. Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions. J Immunol 2009; 182(7):4275-4281. abstract

Rispens T, Ooievaar-De Heer P, Vermeulen E, Schuurman J, van der Neut Kolfschoten M, Aalberse RC. Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions. J Immunol 2009; 182(7):4275-4281. abstract

de Vries MK, Horst-Bruinsma IE, Nurmohamed MT, Aarden LA, Stapel SO, Peters MJ, Van Denderen JC, Dijkmans BA, Wolbink GJ. Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis (AS). Ann Rheum Dis 2009; 68 (4):531-535. abstract

Chapman MD, Pomes A, Aalberse RC. Molecular Biology of Allergens : Structure and Immune Recognition. Allergy Frontiers : Epignetics, Allergens and Risk Factors 2009; :265-289.

Krop EJ, Heederik DJ, Lutter R, de Meer G, Aalberse RC, Jansen HM, van der Zee JS. Associations between pre-employment immunologic and airway mucosal factors and the development of occupational allergy. J Allergy Clin Immunol 2009; 123(3):694-700, 700. abstract

Kerkhof M, Wijga AH, Brunekreef B, Smit HA, de Jongste JC, Aalberse RC, Hoekstra MO, Gerritsen J, Postma DS. Effects of pets on asthma development up to 8 years of age: the PIAMA study. Allergy 2009; 64(8):1202-1208. abstract

Souwer Y, Chamuleau ME, van de Loosdrecht AA, Tolosa E, Jorritsma T, Muris JJ, Dinnissen-van Poppel MJ, Snel SN, van de Corput L, Ossenkoppele GJ, Meijer CJ, Neefjes JJ, van Ham M. Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOA mRNA as a prognostic factor for survival. Br J Haematol 2009; 145(3):334-343. abstract

Souwer Y, Chamuleau ME, van de Loosdrecht AA, Tolosa E, Jorritsma T, Muris JJ, Dinnissen-van Poppel MJ, Snel SN, van de Corp, Ossenkoppele GJ, Meijer CJ, Neefjes JJ, van Ham M. Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOA mRNA as a prognostic factor for survival. Br J Haematol 2009; 145 (3):334-343. abstract

Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy 2009; 39(4):469-477. abstract

Roduit C, Scholtens S, de Jongste JC, Wijga AH, Gerritsen J, Postma DS, Brunekreef B, Hoekstra MO, Aalberse R, Smit HA. Asthma at 8 years of age in children born by caesarean section. Thorax 2009; 64(2):107-113. abstract

Wouters D, van Schouwenburg P, van der Horst A, de Boer M, Schooneman D, Kuijpers TW, Aarden LA, Hamann D. High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA′s. Mol Immunol 2009; 46(4):592-600. abstract

Eekman DA, Hoyer MJ, van Vugt RM, Wolbink GJ, Mulder CJ, Dijkmans BA. Development of Antibodies Against Humanized Antitumor Necrosis Factor and Loss of Efficacy in a Black Spider Monkey With Inflammatory Bowel Disease. J Clin Rheumatol 2009; 15(1):39. abstract

van Ham SM, Samsom JN, Bos NA, Damoiseaux J, Laman JD, Wauben MH. Vaccination immunology: Prevention and beyond NVVI-Dutch society for immunology course Lunteren, 2008, April 3-4. Immunol Lett 2009; 2(2):101-103. abstract

de Vries MK, Horst-Bruinsma IE, Wolbink GJ. Correspondence on: Adalimumab in juvenile rheumatoid arthritis. N Engl J Med 2008; 359(23):2496-2497. abstract

de Vries MK, van der Horst-Bruinsma IE, Wolbink GJ. Correspondence on: Adalimumab in juvenile rheumatoid arthritis. N Engl J Med 2008; 359(23):2496-2497. abstract

Wouters D, van Schouwenburg P, van der Horst A, de Boer M, Schooneman D, Kuijpers TW, Aarden LA, Hamann D. High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA′s. Mol Immunol 2008; 46(4):592-600. abstract

Wouters D, van Schouwenburg P, van der Horst A, de Boer M, Schooneman D, Kuijpers TW, Aarden LA, Hamann D. High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA′s. Mol Immunol 2008; 46 (4):592-600. abstract

Den Bleker T, Derksen N, de Heer P, Vermeulen E, Aalberse R, Rispens T. IgG4, een bijzonder immunoglobuline. Analyse 2008; 63(5):132-138.

Milano F, Jorritsma T, Rygiel AM, Bergman JJ, Sondermeijer C, ten Brinke A, van Ham SM, Krishnadath KK. Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. Scand J Immunol 2008; 68(6):616-623. abstract

Stapel SO, Smeenk RJ. Monoklonale therapeutica en laboratoriumdiagnostiek. Analyse 2008; 63(10):292-324.

van den Bemt BJ, den Broeder AA, Snijders GF, Hekster YA, van Riel PL, Benraad B, Wolbink GJ, van den Hoogen FH. Sustained effect after lowering high-dose infliximab in patients with rheumatoid arthritis: a prospective dose titration study. Ann Rheum Dis 2008; 67(12):1697-1701. abstract

Sancho AI, van Ree R, van Leeuwen A, Meulenbroek BJ, van de Weg EW, Gilissen LJ, Puehringer H, Laimer M, Martinelli A, Zaccharini M, Vazquez-Cortes S, Fernandez-Rivas M, Hoffmann-Sommergruber K, Mills EN, Zuidmeer L. Measurement of lipid transfer protein in 88 apple cultivars. Int Arch Allergy Immunol 2008; 146(1):19-26. abstract

West RL, Zelinkova Z, Wolbink GJ, Kuipers EJ, Stokkers PC, van der Woude CJ. Immunogenicity negatively influences the outcome of adalimumab treatment in Crohn′s disease. Aliment Pharmacol Ther 2008; 28(9):1122-1126. abstract

Torres de Heens GL, Kikkert R, Aarden LA, van der Velden U, Loos BG. Effects of smoking on the ex vivo cytokine production in periodontitis. J Periodontal Res 2009; 44(1):28-34. abstract

Aalberse RC. Allergenicity testing of GM crops. Nat Biotechnol 2008; 26(10):1070-1071. abstract

Bos WH, Bartelds GM, Wolbink GJ, de Koning MH, van de Stadt RJ, van Schaardenburg D, Dijkmans BA, Nurmohamed MT. Differential response of the rheumatoid factor and anticitrullinated protein antibodies during adalimumab treatment in patients with rheumatoid arthritis. J Rheumatol 2008; 35(10):1972-1977. abstract

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008; 40(10):1216-1223. abstract

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008; 40(10):1216-1223. abstract

Rispens T, Lakemond CM, Derksen NI, Aalberse RC. Detection of conformational changes in immunoglobulin G using isothermal titration calorimetry with low-molecular-weight probes. Anal Biochem 2008; 380(2):303-309. abstract

Bos WH, Ursum J, de Vries N, Bartelds GM, Wolbink GJ, Nurmohamed MT, Horst-Bruinsma IE, van de Stadt RJ, Crusius JB, Tak PP, Dijkmans BA, van Schaardenburg D. The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels. Ann Rheum Dis 2008; 67(9):1347-1350. abstract

Bos WH, Ursum J, de Vries N, Bartelds GM, Wolbink GJ, Nurmohamed MT, van der Horst-Bruinsma IE, van de Stadt RJ, Crusius JB, Tak PP, Dijkmans BA, van Schaardenburg D. The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels. Ann Rheum Dis 2008; 67(9):1347-1350. abstract

van der Laken CJ, Voskuyl AE, Roos JC, Stigter van Walsum M, de Groot ER, Wolbink GJ, Dijkmans BAC, Aarden LA. Het ontstaan van immuuncomplexen van infliximab en anti-infliximab als een verklaring voor het falen van infliximabtherapie bij reumatoïde artritis: observationeel onderzoek bij 4 patiënten [The formation of infliximab and anti-infliximab immune complexes as an explanation for non-responding to infliximab treatment of rheumatoid arthritis: observational study in 4 patients]. Ned Tijdschr Geneeskd 2008; 152(30):1672-1677. abstract

Zeerleder S, Zwart B, te Velthuis H, Stephan F, Manoe R, Rensink I, Aarden LA. Nucleosome-releasing factor: a new role for factor VII-activating protease (FSAP). FASEB J 2008; 22(12):4077-4084. abstract

Zeerleder S, Zwart B, te Velthuis H, Stephan F, Manoe R, Rensink I, Aarden LA. Nucleosome-releasing factor: a new role for factor VII-activating protease (FSAP). FASEB J 2008; 22 (12):4077-4084. abstract

Labrijn AF, Aalberse RC, Schuurman J. When binding is enough: nonactivating antibody formats. Curr Opin Immunol 2008; 20(4):479-485. abstract

Stapel SO, Smeenk RJ. Monoklonale therapeutica en laboratoriumdiagnostiek. Analyse 2008; 63(10):292-324.

Ursum J, Nielen MM, van Schaardenburg D, van der Horst AR, van de Stadt RJ, Dijkmans BA, Hamann D. Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study. Arthritis Res Ther 2008; 10(1):1-6. abstract

van der Laken CJ, Voskuyl AE, Roos JC, Stigter van Walsum M, de Groot ER, Wolbink GJ, Dijkmans BAC, Aarden LA. Het ontstaan van immuuncomplexen van infliximab en anti-infliximab als een verklaring voor het falen van infliximabtherapie bij reumato‹de artritis: observationeel onderzoek bij 4 pati‰nten [The formation of infliximab and anti-infliximab immune complexes as an explanation for non-responding to infliximab treatment of rheumatoid arthritis: observational study in 4 patients]. Ned Tijdschr Geneeskd 2008; 152(30):1672-1677. abstract

Wouters D, Wagenaar-Bos I, van Ham M, Zeerleder S. C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther 2008; 8(8):1225-1240. abstract

Wouters D. Assessment of complement activation in human disease. University of Amsterdam, Amsterdam, June 19, 2008;

Wagenaar-Bos IG, Drouet C, Aygoren-Pursun E, Bork K, Bucher C, Bygum A, Farkas H, Fust G, Gregorek H, Hack CE, Hickey A, Joller-Jemelka HI, Kapusta M, Kreuz W, Longhurst H, Lopez-Trascasa M, Madalinski K, Naskalski J, Nieuwenhuys E, Ponard D, Truedsson L, Varga L, Nielsen EW, Wagner E, Zingale L, Cicardi M, van Ham SM. Functional C1-Inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations. J Immunol Methods 2008; 338(1-2):14-20. abstract

Wagenaar-Bos IG, Drouet C, Aygoren-Pursun E, Bork K, Bucher C, Bygum A, Farkas H, Fust G, Gregorek H, Hack CE, Hickey A, Joller-Jemelka HI, Kapusta M, Kreuz W, Longhurst H, Lopez-Trascasa M, Madalinski K, Naskalski J, Nieuwenhuys E, Ponard D, Truedsson L, Varga L, Nielsen EW, Wagner E, Zingale L, Cicardi M, van Ham SM. Functional C1-Inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations. J Immunol Methods 2008; 338 (1-2):14-20. abstract

Aarden L, Ruuls SR, Wolbink G. Immunogenicity of anti-tumor necrosis factor antibodies-toward improved methods of anti-antibody measurement. Curr Opin Immunol 2008; 20(4):431-435. abstract

Aarden L, Ruuls SR, Wolbink G. Immunogenicity of anti-tumor necrosis factor antibodies-toward improved methods of anti-antibody measurement. Curr Opin Immunol 2008; 20 (4):431-435. abstract

Mari A, Ooievaar-De Heer P, Scala E, Giani M, Pirrotta L, Zuidmeer L, Bethell D, van Ree R. Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans. Allergy 2008; 63(7):891-896. abstract

van Deutekom AW, Nurmohamed MT, Peters MJ, van Eijk IC, Dijkmans BA, Hamann D, Heine RJ, Simsek S. Methotrexate and its effect on the anti-GAD titre in two patients with rheumatoid arthritis and diabetes mellitus. Ann Rheum Dis 2008; 67(7):1051-1052. abstract

Hack KEA, Khodabux CM, von Lindern JS, Brouwers HA, Scherjon SA, van Rijn HJ, van Hilten JA, Brand A, Page-Christiaens GC. Bloedtransfusiebehoefte bij prematuren in 2 Nederlandse perinatologische centra sterk bepaald door bloedafname voor diagnostiek [Need for blood transfusion in premature infants in 2 Dutch perinatology centres particularly determined by blood sampling for diagnosis]. Ned Tijdschr Geneeskd 2008; 152(25):1419-1425. abstract

Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133(6):1019-1031. abstract

Bem RA, Bos AP, Bots M, Wolbink AM, van Ham SM, Medema JP, Lutter R, van Woensel JB. Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. Pediatr Res 2008; 63(6):650-655. abstract

Voorberg J. Slipping out the Weibel-Palade body. Blood 2008; 111(11):5264-5265. abstract

Wouters D. Assessment of complement activation in human disease. University of Amsterdam, Amsterdam, June 19, 2008;

Bos WH, Bartelds GM, Vis M, van der Horst AR, Wolbink GJ, van de Stadt R, van Schaardenburg D, Dijkmans BA, Lems WF, Nurmohamed MT, Aarden L, Hamann D. Preferential decrease of IgG4 anti-citrullinated protein antibodies during treatment with TNF blocking agents in patients with rheumatoid arthritis. Ann Rheum Dis 2008; 68(4):558-563. abstract

Kikkert R, de Groot ER, Aarden LA. Cytokine induction by pyrogens: Comparison of whole blood, mononuclear cells, and TLR-transfectants. J Immunol Methods 2008; 336(1):45-55. abstract

Kikkert R, de Groot ER, Aarden LA. Cytokine induction by pyrogens: Comparison of whole blood, mononuclear cells, and TLR-transfectants. J Immunol Methods 2008; 336 (1):45-55. abstract

Brinkman HJ, van Mourik JA, Mertens K. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor. Blood Coagul Fibrinolysis 2008; 19(3):190-196. abstract

Ramaglia V, Wolterman R, de Kok M, Vigar MA, Wagenaar-Bos I, King RH, Morgan BP, Baas F. Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury. Am J Pathol 2008; 172(4):1043-1052. abstract

Santos AB, Rocha GM, Oliver C, Ferriani VP, Lima RC, Palma MS, Sales VS, Aalberse RC, Chapman MD, Arruda LK. Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach. J Allergy Clin Immunol 2008; 121(4):1040-1046. abstract

van Beem RT, Noort WA, Voermans C, Kleijer M, ten Brinke A, van Ham SM, van der Schoot CE, Zwaginga JJ. The Presence of Activated CD4+ T Cells Is Essential for the Formation of Colony-Forming Unit-Endothelial Cells by CD14+ Cells. J Immunol 2008; 180(7):5141-5148. abstract

Wouters D, Brouwer MC, Daha MR, Hack CE. Studies on the haemolytic activity of circulating C1q-C3/C4 complexes. Mol Immunol 2008; 45(7):1893-1899. abstract

de Vries MK, van der Horst-Bruinsma IE, Nurmohamed MT, Aarden LA, Stapel SO, Peters MJ, Van Denderen JC, Dijkmans BA, Wolbink GJ. Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis (AS). Ann Rheum Dis 2009; 68(4):531-535. abstract

Watchmaker PB, Urban JA, Berk E, Nakamura Y, Mailliard RB, Watkins SC, van Ham SM, Kalinski P. Memory CD8+ T cells protect dendritic cells from CTL killing. J Immunol 2008; 180(6):3857-3865. abstract

Ursum J, Nielen MM, van Schaardenburg D, van der Horst AR, van de Stadt RJ, Dijkmans BA, Hamann D. Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study. Arthritis Res Ther 2008; 10(1):1-6. abstract

van Ree R, Chapman MD, Ferreira F, Vieths S, Bryan D, Cromwell O, Villalba M, Durham SR, Becker WM, Aalbers M, Andre C, Barber D, Cistero-Bahima A, Custovic A, Didierlaurent A, Dolman C, Dorpema JW, Di Felice G, Eberhardt F, Fernandez Caldas E, Fernandez Rivas M, Fiebig H, Focke M, Fotisch K, Gadermaier G, Das RG, Gonzalez Mancebo E, Himly M, Kinaciyan T, Knulst AC, Kroon AM, Lepp U, Marco FM, Mari A, Moingeon P, Monsalve R, Neubauer A, Notten S, Ooievaar-De Heer P, Pauli G, Pini C, Purohit A, Quiralte J, Rak S, Raulf-Heimsoth M, San Miguel Moncin MM, Simpson B, Tsay A, Vailes L, Wallner M, Weber B. The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy 2008; 63(3):310-326. abstract

Vis M, Bos WH, Wolbink G, Voskuyl AE, Twisk JW, van de Stadt R, Hamann D, Dijkmans BA, Lems WF. IgM-rheumatoid factor, anti-cyclic citrullinated peptide, and anti-citrullinated human fibrinogen antibodies decrease during treatment with the tumor necrosis factor blocker infliximab in patients with rheumatoid arthritis. J Rheumatol 2008; 35(3):425-428. abstract

Host A, Halken S, Muraro A, Dreborg S, Niggemann B, Aalberse R, Arshad SH, von Berg A, Carlsen KH, Duschen K, Eigenmann PA, Hill D, Jones C, Mellon M, Oldeus G, Oranje A, Pascual C, Prescott S, Sampson H, Svartengren M, Wahn U, Warner JA, Warner JO, Vandenplas Y, Wickman M, Zeiger RS. Dietary prevention of allergic diseases in infants and small children. Pediatr Allergy Immunol 2008; 19(1):1-4. abstract

Schreuder TC, Gelderblom HC, Weegink CJ, Hamann D, Reesink HW, Devries JH, Hoekstra JB, Jansen PL. High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection. Liver Int 2008; 28(1):39-46. abstract

van Till JW, Modderman PW, de Boer M, Hart MH, Beld MG, Boermeester MA. Mannose-binding lectin deficiency facilitates abdominal yeast infection in patients with secondary peritonitis. Clin Vaccine Immunol 2008; 15(1):65-70. abstract

Milano F, Rygiel AM, Buttar N, Bergman JJ, Sondermeijer C, van Baal JW, ten Brinke A, Kapsenberg M, van Ham SM, Peppelenbosch MP, Krishnadath KK. An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer. Cancer Immunol Immunother 2007; 56(12):1967-1977. abstract

Wouters D, Brouwer MC, Daha MR, Hack CE. Studies on the haemolytic activity of circulating C1q-C3/C4 complexes. Mol Immunol 2007; 45(7):1893-1899. abstract

Wouters D, Brouwer MC, Daha MR, Hack CE. Studies on the haemolytic activity of circulating C1q-C3/C4 complexes. Mol Immunol 2007; 45 (7):1893-1899. abstract

Zeerleder S. Studies on inflammatory and coagulation pathways in humans with sepsis. University of Amsterdam, Amsterdam, February 1, 2007;

Diaz Padilla N, van Vliet AK, Schoots IG, Seron MV, Maas MA, Peltenburg EE, de Vries A, Niessen HW, Hack CE, van Gulik TM. C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. Surgery 2007; 142(5):722-733. abstract

Kremer Hovinga JA, Zeerleder S, Kessler P, Romani de Wit T, van Mourik JA, Hack CE, ten Cate H, Reitsma PH, Wuillemin WA, Lammle B. ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 2007; 5(11):2284-2290. abstract

van Till JW, Modderman PW, de Boer M, Hart MH, Beld MG, Boermeester MA. Mannose-binding lectin deficiency facilitates abdominal yeast infection in patients with secondary peritonitis. Clin Vaccine Immunol 2008; 15(1):65-70. abstract

Zeerleder S, Zwart B, te Velthuis H, Manoe R, Bulder I, Rensink I, Aarden LA. A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells. FEBS Lett 2007; 581(28):5382-5388. abstract

Zeerleder S, Zwart B, te Velthuis H, Manoe R, Bulder I, Rensink I, Aarden LA. A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells. FEBS Lett 2007; 581 (28):5382-5388. abstract

Diaz Padilla N. Role of IgM and C-reactive protein in ischemia reperfusion injury. Leiden University, Leiden, September 13, 2007;

Govers-Riemslag JW, Smid M, Cooper JA, Bauer KA, Rosenberg RD, Hack CE, Hamulyak K, Spronk HM, Miller GJ, ten Cate H. The plasma kallikrein-kinin system and risk of cardiovascular disease in men. J Thromb Haemost 2007; 5(9):1896-1903. abstract

van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martinez-Martinez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, de Baets MH, van de Winkel JGJ, Aalberse RC, Parren PWHI. Anti-Inflammatory Activity of Human IgG4 antibodies by Dynamic Fab Arm Exchange. Science 2007; 317:1554-1557.

ten Brinke A, Karsten ML, Dieker MC, Zwaginga JJ, van Ham SM. The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization. Vaccine 2007; 25(41):7145-7152. abstract

ten Brinke A, Karsten ML, Dieker MC, Zwaginga JJ, van Ham SM. The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization. Vaccine 2007; 25 (41):7145-7152. abstract

Diaz Padilla N. Role of IgM and C-reactive protein in ischemia reperfusion injury. Leiden University, Leiden, September 13, 2007;

Krop EJ, Matsui EC, Sharrow SD, Stone MJ, Gerber P, van der Zee JS, Chapman MD, Aalberse RC. Recombinant major urinary proteins of the mouse in specific IgE and IgG testing. Int Arch Allergy Immunol 2007; 144(4):296-304. abstract

Kummer JA, Micheau O, Schneider P, Bovenschen N, Broekhuizen R, Quadir R, Strik MC, Hack CE, Tschopp J. Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis. Cell Death Differ 2007; 14(8):1486-1496. abstract

Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martinez-Martinez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, de Baets MH, van de Winkel JGJ, Aalberse RC, Parren PWHI. Anti-Inflammatory Activity of Human IgG4 antibodies by Dynamic Fab Arm Exchange. Science 2007; 317:1554-1557.

Tang H, Ivanciu L, Popescu N, Peer G, Hack E, Lupu C, Taylor FB, Lupu F. Sepsis-Induced Coagulation in the Baboon Lung Is Associated with Decreased Tissue Factor Pathway Inhibitor. Am J Pathol 2007; 171(3):1066-1077. abstract

Tang H, Ivanciu L, Popescu N, Peer G, Hack E, Lupu C, Taylor FB, Lupu F. Sepsis-Induced Coagulation in the Baboon Lung Is Associated with Decreased Tissue Factor Pathway Inhibitor. Am J Pathol 2007; 171 (3):1066-1077. abstract

Kikkert R, Bulder I, de Groot ER, Aarden LA, Finkelman MA. Potentiation of Toll-like receptor-induced cytokine production by (1?3)-?-D-glucans: implications for the monocyte activation test. J Endotoxin Res 2007; 13(3):140-149. abstract

Peters MJ, Vis M, van Halm VP, Wolbink GJ, Voskuyl AE, Lems WF, Dijkmans BA, Twisk JW, de Koning MH, van de Stadt RJ, Nurmohamed MT. Changes in lipid profile during infliximab and corticosteroid treatment in rheumatoid arthritis. Ann Rheum Dis 2007; 66(7):958-961. abstract

Poole J, Tilley L, Warke N, Spring FA, Overbeeke MA, Mark-Zoet JA, Ahrens N, Armstrong D, Williams M, Daniels G. Two missense mutations in the CD44 gene encode two new antigens of the Indian blood group system. Transfusion 2007; 47(7):1306-1311. abstract

Poole J, Tilley L, Warke N, Spring FA, Overbeeke MA, van der Mark-Zoet JA, Ahrens N, Armstrong D, Williams M, Daniels G. Two missense mutations in the CD44 gene encode two new antigens of the Indian blood group system. Transfusion 2007; 47(7):1306-1311. abstract

Zwijnenburg PJ, van der Poll T, Florquin S, Polfliet MM, van den Berg TK, Dijkstra CD, Roord JJ, Hack CE, van Furth AM. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J Infect Dis 2007; 196(1):115-123. abstract

Kikkert R, Laine ML, Aarden LA, van Winkelhoff AJ. Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria. Oral Microbiol Immunol 2007; 22(3):145-151. abstract

Strik MC, de Koning PJ, Kleijmeer MJ, Bladergroen BA, Wolbink AM, Griffith JM, Wouters D, Fukuoka Y, Schwartz LB, Hack CE, van Ham SM, Kummer JA. Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation. Mol Immunol 2007; 44(14):3462-3472. abstract

Strik MC, de Koning PJ, Kleijmeer MJ, Bladergroen BA, Wolbink AM, Griffith JM, Wouters D, Fukuoka Y, Schwartz LB, Hack CE, van Ham SM, Kummer JA. Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation. Mol Immunol 2007; 44 (14):3462-3472. abstract

de Vries MK, Wolbink GJ, Stapel S, de Vrieze H, Van Denderen JC, Dijkmans BA, Aarden L, Horst-Bruinsma IE. Decreased clinical response to infliximab in Ankylosing Spondylitis (AS) is correlated with anti-infliximab formation. Ann Rheum Dis 2007; 66 (9 ):1252-1254. abstract

de Vries MK, Wolbink GJ, Stapel S, de Vrieze H, Van Denderen JC, Dijkmans BA, Aarden L, van der Horst-Bruinsma IE. Decreased clinical response to infliximab in Ankylosing Spondylitis (AS) is correlated with anti-infliximab formation. Ann Rheum Dis 2007; 66(9):1252-1254. abstract

Biezeveld MH. Genes and Protein in Kawasaki Disease. University of Amsterdam, Amsterdam, March 28, 2007;

Krop EJ, Doekes G, Stone MJ, Aalberse RC, van der Zee JS. Spreading of occupational allergens: laboratory animal allergens on hair-covering caps and in mattress dust of laboratory animal workers. Occup Environ Med 2007; 64(4):267-272. abstract

Kikkert R, Bulder I, de Groot ER, Aarden LA, Finkelman MA. Potentiation of Toll-like receptor-induced cytokine production by (1?3)-?-D-glucans: implications for the monocyte activation test. J Endotoxin Res 2007; 13(3):140-149. abstract

Krop EJ, Matsui EC, Sharrow SD, Stone MJ, Gerber P, van der Zee JS, Chapman MD, Aalberse RC. Recombinant major urinary proteins of the mouse in specific IgE and IgG testing. Int Arch Allergy Immunol 2007; 144(4):296-304. abstract

Zeerleder S, Schroeder V, Lammle B, Wuillemin WA, Hack CE, Kohler HP. Factor XIII in severe sepsis and septic shock. Thromb Res 2007; 119 :311-318. abstract

Bartelds GM, Wijbrandts CA, Nurmohamed MT, Stapel S, Lems WF, Aarden L, Dijkmans BA, Tak P, Wolbink GJ. Clinical response to adalimumab: The relationship with anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann Rheum Dis 2007; 66:921-926. abstract

Aalberse RC. Assessment of allergen cross-reactivity. Clin Mol Allergy 2007; 5(2):1-6. abstract

Oedayrajsingh Varma M, Breuls RG, Schouten TE, Jurgens WJ, Bontkes HJ, Schuurhuis GJ, van Ham SM, van Milligen FJ. Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev 2007; 16(1):91-104. abstract

van der Laken CJ, Voskuyl AE, Roos JC, Stigter van Walsum M, de Groot ER, Wolbink G, Dijkmans BA, Aarden LA. Imaging and serum analysis of immune complex formation of radiolabeled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis. Ann Rheum Dis 2007; 66 (2):253-256. abstract

Varma MJ, Breuls RG, Schouten TE, Jurgens WJ, Bontkes HJ, Schuurhuis GJ, van Ham SM, van Milligen FJ. Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev 2007; 16(1):91-104. abstract

Zeerleder S. Studies on inflammatory and coagulation pathways in humans with sepsis. University of Amsterdam, Amsterdam, February 1, 2007;

de Vries MK, Wolbink GJ, Stapel SO, de Groot ER, Dijkmans BA, Aarden LA, van der Horst-Bruinsma IE. Inefficacy of infliximab in ankylosing spondylitis is correlated with antibody formation. Ann Rheum Dis 2007; 66(1):133-134. abstract

Lienard D, Dinh OT, van Oort E, Van Overtvelt L, Bonneau C, Wambre E, Bardor M, Cosette P, Didier-Laurent A, de Borne FD, Delon R, van Ree R, Moingeon P, Faye L, Gomord V. Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens. Plant Biotechnol J 2007; 5(1):93-108. abstract

Bultink IE, Hamann D, Seelen MA, Hart MH, Dijkmans BA, Daha MR, Voskuyl AE. Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus (SLE). Arthritis Res Ther 2006; 8(6):R183-1-10. abstract

Bultink IE, Hamann D, Seelen MA, Hart MH, Dijkmans BA, Daha MR, Voskuyl AE. Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus (SLE). Arthritis Res Ther 2006; 8(6):R183-10. abstract

Antens CJ, Oldenwening M, Wolse A, Gehring U, Smit HA, Aalberse RC, Kerkhof M, Gerritsen J, de Jongste JC, Brunekreef B. Repeated measurements of mite and pet allergen levels in house dust over a time period of 8 years. Clin Exp Allergy 2006; 36(12):1525-1531. abstract

Keller TT, Choi D, Nagel C, te Velthuis H, Gerdes VE, Wareham NJ, Bingham SA, Luben R, Hack CE, Reitsma PH, Levi M, Khaw KT, Boekholdt SM. Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. J Thromb Haemost 2006; 4(11):2391-2396. abstract

Wagenaar-Bos IG, Hack CE. Structure and function of c1-inhibitor. Immunol Allergy Clin North Am 2006; 26(4):615-632. abstract

Bouman CS, de Pont AC, Meijers JC, Bakhtiari K, Roem D, Zeerleder S, Wolbink G, Korevaar JC, Levi M, de Jonge E. The effects of continuous venovenous hemofiltration on coagulation activation. Crit Care 2006; 10(5):R150. abstract

van Till JWO, Boermeester MA, Modderman PW, Sandick JW, Hart MH, Gisbertz SS, Lanschot JJ, Aarden LA. Variable Mannose-Binding Lectin Expression during Postoperative Acute-Phase Response. Surg Infect 2006; 7(5):443-452. abstract

Baidoshvili A, Krijnen PA, Kupreishvili K, Ciurana C, Bleeker W, Nijmeijer R, Visser CA, Visser FC, Meijer CJ, Stooker W, Eijsman L, van Hinsbergh VW, Hack CE, Niessen HW, Schalkwijk CG. N{varepsilon}-(Carboxymethyl)lysine Depositions in Intramyocardial Blood Vessels in Human and Rat Acute Myocardial Infarction. A Predictor or Reflection of Infarction?. Arterioscler Thromb Vasc Biol 2006; 26(11):2497-2503. abstract

Bartelds GM, Wolbink GJ, Stapel S, Aarden L, Lems WF, Dijkmans BA, Nurmohamed MT. High levels of human anti-human antibodies to adalimumab in a patient not responding to adalimumab treatment. Ann Rheum Dis 2006; 65(9):1249-1250. abstract

ten Brinke A, Karsten ML, Dieker MC, Zwaginga JJ, Vrielink H, van Ham M. Generation of dendritic cells for immunotherapy is minimally impaired by granulocytes in the monocyte preparation. Immunobiology 2006; 211(6-8):633-640. abstract

Voves C, Wuillemin WA, Zeerleder S. International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. Blood Coagul Fibrinolysis 2006; 17(6):445-451. abstract

Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res 2006; 118(2):205-212. abstract

Aalberse RC. Structural features of allergenic molecules. Allergy and Asthma in Modern Society : A Scientific Approach 2006; 91:134-146. abstract

Fernandez-Rivas M, Bolhaar S, Gonzalez-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, Miles S, Zuidmeer L, Knulst A, Breiteneder H, Mills C, Hoffmann-Sommergruber K, van Ree R. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 2006; 118(2):481-488. abstract

Matsui EC, Diette GB, Krop EJ, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen-specific immunoglobulin G4 and risk of mouse skin test sensitivity. Clin Exp Allergy 2006; 36(8):1097-1103. abstract

Oedayrajsingh-Varma M, van Ham S, Knippenberg M, Helder M, Klein-Nulend J, Schouten T, Ritt M, van Milligen F. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006; 8(2):166-177. abstract

ten Brinke A, Karsten ML, Dieker MC, Zwaginga JJ, Vrielink H, van Ham M. Generation of dendritic cells for immunotherapy is minimally impaired by granulocytes in the monocyte preparation. Immunobiology 2006; 211(6-8):633-640. abstract

Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res 2006; 118(2):205-212. abstract

Tschopp CM, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow JC, Hack CE, Dahinden CA. Granzyme B, a novel mediator of allergic inflammation: Its induction and release in blood basophils and human asthma. Blood 2006; 108(7):2290. abstract

van der Laken CJ, Voskuyl AE, Roos JC, Stigter van Walsum M, de Groot ER, Wolbink G, Dijkmans BA, Aarden LA. Imaging and serum analysis of immune complex formation of radiolabeled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis. Ann Rheum Dis 2007; 66(2):253-256. abstract

Aalberse RC, Stadler BM. In silico predictability of allergenicity: From amino acid sequence via 3-D structure to allergenicity. Mol Nutr Food Res 2006; 50:625-627. abstract

Hollestelle MJ, Donkor C, Mantey EA, Chakravorty SJ, Craig A, Osei Akoto A, O'donnell J, van Mourik JA, Bunn J. Von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol 2006; 133(5):562-569. abstract

Zeerleder S. The struggle to detect circulating DNA. Crit Care 2006; 10(3):142-144. abstract

Oedayrajsingh-Varma M, van Ham S, Knippenberg M, Helder M, Klein-Nulend J, Schouten T, Ritt M, van Milligen F. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006; 8(2):166-177. abstract

Ciurana CL, Hack CE. Competitive binding of pentraxins and IgM to newly exposed epitopes on late apoptotic cells. Cell Immunol 2006; 239(1):14-21. abstract

Levi M, Choi G, Picavet C, Hack CE. Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency. J Allergy Clin Immunol 2006; 117(4):904-908. abstract

Wouters D, Voskuyl AE, Molenaar ET, Dijkmans BA, Hack CE. Evaluation of classical complement pathway activation in rheumatoid arthritis: Measurement of C1q-C4 complexes as novel activation products. Arthritis Rheum 2006; 54(4):1143-1150. abstract

Zeerleder S, Schroeder V, Lammle B, Wuillemin WA, Hack CE, Kohler HP. Factor XIII in severe sepsis and septic shock. Thromb Res 2007; 119:311-318. abstract

Aalberse RC. Structural features of allergenic molecules. Allergy and Asthma in Modern Society : A Scientific Approach 2006; 91:134-146. abstract

McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE, Roos A. Evidence That Complement Protein C1q Interacts with C-Reactive Protein through Its Globular Head Region. J Immunol 2006; 176(5):2950-2957. abstract

Wolbink GJ, Vis M, Lems W, Voskuyl AE, de Groot E, Nurmohamed MT, Stapel S, Tak PP, Aarden L, Dijkmans B. Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 2006; 54(3):711-715. abstract

Akkerdaas JH, Schocker F, Vieths S, Versteeg S, Zuidmeer L, Hefle SL, Aalberse RC, Richter K, Ferreira F, van Ree R. Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. Mol Nutr Food Res 2006; 50(1):18-23. abstract

Heijnen BH, Straatsburg IH, Diaz Padilla N, van Mierlo GJ, Hack CE, van Gulik TM. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Clin Exp Immunol 2006; 143(1):15-23. abstract

Bolhaar ST, Zuidmeer L, Ma Y, Ferreira F, Bruijnzeel-Koomen CA, Hoffmann-Sommergruber K, van Ree R, Knulst AC. A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge. Clin Exp Allergy 2005; 35(12):1638-1644. abstract

Rowshani AT, Strik MC, Molenaar R, Yong SL, Wolbink AM, Bemelman FJ, Hack CE, ten Berge IJ. The Granzyme B Inhibitor SERPINB9 (Protease Inhibitor 9) Circulates in Blood and Increases on Primary Cytomegalovirus Infection after Renal Transplantation. J Infect Dis 2005; 192(11):1908-1911. abstract

van der Putten RF, te Velthuis H, Aarden LA, ten Cate H, Glatz JF, Hermens WT. High-affinity antibodies in a new immunoassay for plasma tissue factor: reduction in apparent intra-individual variation. Clin Chem Lab Med 2005; 43(12):1386-1391. abstract

Akkerdaas JH, Schocker F, Vieths S, Versteeg S, Zuidmeer L, Hefle SL, Aalberse RC, Richter K, Ferreira F, van Ree R. Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. Mol Nutr Food Res 2005; 50:18-23. abstract

Bolhaar ST, van de Weg WE, van Ree R, Gonzalez-Mancebo E, Zuidmeer L, Bruijnzeel-Koomen CA, Fernandez-Rivas M, Jansen J, Hoffmann-Sommergruber K, Knulst AC, Gilissen LJ. In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars. J Allergy Clin Immunol 2005; 116(5):1080-1086. abstract

de Bruin EC, Roem D, Bulder I, Dieker M, Voerman G, Hack CE. Production, purification and characterisation of recombinant Fahsin, a novel antistasin-type proteinase inhibitor. FEMS Yeast Res 2005; 5(11):1069-1077. abstract

Krijnen PA, Cillessen SA, Manoe R, Muller A, Visser CA, Meijer CJ, Musters RJ, Hack CE, Aarden LA, Niessen HW. Clusterin: a protective mediator for ischemic cardiomyocytes?. Am J Physiol Heart Circ Physiol 2005; 289(5):H2193-H2202. abstract

Ludwig S, Dharmalingam S, Erickson-Nesmith S, Ren S, Zhu F, Ma GM, Zhao R, Fenton JW, Ofosu FA, te Velthuis H, van Mierlo G, Shen GX. Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus. Diabetes Res Clin Pract 2005; 70(2):110-118. abstract

Wolbink GJ, Voskuyl A, Lems W, de Groot E, Nurmohamed MT, Tak PP, Dijkmans BA, Aarden L. Relation between serum trough infliximab levels, pre- treatment CRP levels and clinical response to infliximab treatment in rheumatoid arthritis. Ann Rheum Dis 2005; 64:704-707. abstract

Akkerdaas JH, Wensing M, Asero R, Rivas MF, Knulst AC, Bolhaar S, Hefle SL, Aalberse RC, van Ree R. IgE Binding to Pepsin-Digested Food Extracts. Int Arch Allergy Immunol 2005; 138(3):203-208. abstract

Akkerdaas JH. Identification and quantification of hazelnut allergens. University of Amsterdam, Amsterdam, November 2, 2005;

Bade B, Lohrmann J, ten Brinke A, Wolbink AM, Wolbink GJ, Berge IJ, Virchow JC, Luttmann W, Hack CE. Detection of soluble human granzyme K in vitro and in vivo. Eur J Immunol 2005; 35(10):2940-2948. abstract

Diemel RV, Ter Hart HG, Derksen GJ, Koenderman AH, Aalberse RC. Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products. Transfusion 2005; 45(10):1601-1609. abstract

Matsui EC, Diette GB, Krop EJ, Aalberse RC, Smith AL, Curtin-Brosnan J, Eggleston PA. Mouse allergen-specific immunoglobulin G and immunoglobulin G4 and allergic symptoms in immunoglobulin E-sensitized laboratory animal workers. Clin Exp Allergy 2005; 35(10):1347-1353. abstract

Sancho AI, Rigby NM, Zuidmeer L, Asero R, Mistrello G, Amato S, Gonzalez-Mancebo E, Fernandez-Rivas M, van Ree R, Mills EN. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy 2005; 60(10):1262-1268. abstract

van der Putten RF, te Velthuis HT, de Zwaan C, Aarden LA, Glatz JF, Hermens WT. State and diagnostic value of plasma tissue factor in early-hospitalised patients with chest pain. Br J Haematol 2005; 131(1):91-99. abstract

van Doorn MB, Burggraaf J, van Dam T, Eerenberg A, Levi M, Hack CE, Schoemaker RC, Cohen AF, Nuijens J. A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema. J Allergy Clin Immunol 2005; 116(4):876-883. abstract

Aalberse RC. Assessment of sequence homology and cross-reactivity. Toxicol Appl Pharmacol 2005; 207(2 Suppl):149-151. abstract

de Bruin EC, Duitman EH, de Boer AL, Veenhuis M, Bos IG, Hack CE. Pharmaceutical proteins from methylotrophic yeasts. Therapeutic Proteins : Methods and Protocols 2005; 308(6):65-76. abstract

Moons AH, van der Zee PM, Bholasingh R, Sturk A, Hack CE, Meijers JC, Kamp O, Cornel JH, Peters RJ, de Winter RJ. The value of haemostatic markers in the triage of patients with chest pain presenting with a normal or non-diagnostic ECG. Heart 2005; 91(9):1215-1216. abstract

van Woensel JB, Biezeveld MH, Hack CE, Bos AP, Kuijpers TW. Elastase and granzymes during meningococcal disease in children: correlation to disease severity. Intensive Care Med 2005; 31(9):1239-1247. abstract

Aalberse RC, Stapel SO. What can we learn from the ration of IgG1/IgG4 antibodies to allergens?. From Genes to Phenotypes : The basis of Future Allergy Management : Proc. of the 25th Symposium of the Collegium Internationale Allergologicum : Allergy & Clinical Immunology International - Journal of the World Allergy Organization, Supplement 2, 2005 2005; :190-192.

Akkerdaas JH. Identification and quantification of hazelnut allergens. University of Amsterdam, Amsterdam, November 2, 2005;

Brunekreef B, van Strien R, Pronk A, Oldenwening M, de Jongste JC, Wijga A, Kerkhof M, Aalberse RC. La mano de DIOS...was the PIAMA intervention study intervened upon?. Allergy 2005; 60(8):1083-1086. abstract

de Bruin EC, Duitman EH, de Boer AL, Veenhuis M, Bos IG, Hack CE. Pharmaceutical proteins from methylotrophic yeasts. Therapeutic Proteins : Methods and Protocols 2005; 308(6):65-76. abstract

Familian A. Studies on pentraxin mediated complement activation. Free University of Amsterdam, Amsterdam, April 15, 2005;

Mairuhu AT, Peri G, Setiati TE, Hack CE, Koraka P, Soemantri A, Osterhaus AD, Brandjes DP, van der Meer JW, Mantovani A, van Gorp EC. Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections. J Med Virol 2005; 76(4):547-552. abstract

Strik MCM. The (patho-)physiological role of intracellular serine protease inhibitor. Free University (VU), Amsterdam, April 20, 2005;

van Mirre E. Novel insights in human Fcgamma-receptors and IgG : on genes, transcripts and functional interactions. University of Amsterdam (UvA), Amsterdam, October 20, 2005;

Wilcock LK, Wachholz PA, Hae-Won Na D, Aalberse RC, Larsen JN, Francis JN, Durham SR. Inhibition of IgE-Facilitated Allergen Presentation : A Longitudinal Study of Grass Pollen Immunotherapy. From Genes to Phenotypes : The basis of Future Allergy Management : Proc. of the 25th Symposium of the Collegium Internationale Allergologicum : Allergy & Clinical Immunology International - Journal of the World Allergy Organization, Supplement 2, 2005 2005; :244-247.

Zeerleder S, Hack CE, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Wolbink A, Wuillenmin WA. Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction. Clin Immunol 2005; 116(2):158-165. abstract

Haanen JB, Baars A, Gomez R, Weder P, Smits M, de Gruijl TD, von Blomberg BM, Bloemena E, Scheper RJ, van Ham SM, Pinedo HM, van den Eertwegh AJ. Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients. Cancer Immunol Immunother 2006; 55(4):451-458. abstract

Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res 2005; 118(2):205-212. abstract

Aarden L. From poisson distribution to interleukins. Scand J Immunol 2005; 62 Suppl 1:33-35. abstract

Ballmer-Weber BK, Wangorsch A, Bohle B, Kaul S, Kundig T, Fotisch K, van Ree R, Vieths S. Component-resolved in vitro diagnosis in carrot allergy: does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?. Clin Exp Allergy 2005; 35(7):970-978. abstract

Biezeveld MH, van Mierlo G, Lutter R, Kuipers IM, Dekker T, Hack CE, Newburger JW, Kuijpers TW. Sustained activation of neutrophils in the course of Kawasaki disease: an association with matrix metalloproteinases. Clin Exp Immunol 2005; 141(1):183-188. abstract

Familian A, Voskuyl AE, van Mierlo GJ, Heijst HA, Twisk JW, Dijkmans BA, Hack CE. Infliximab treatment reduces complement activation in patients with rheumatoid arthritis. Ann Rheum Dis 2005; 64(7):1003-1008. abstract

Zuidmeer L, van Leeuwen WA, Kleine Budde I, Cornelissen J, Bulder I, Rafalska I, Telle Besoli N, Akkerdaas JH, Asero R, Fernandez Rivas M, Gonzalez Mancebo E, van Ree R. Lipid Transfer Proteins from Fruit: Cloning, Expression and Quantification. Int Arch Allergy Immunol 2005; 137(4):273-281. abstract

Goldbach-Mansky R, Suson S, Wesley R, Hack CE, El Gabalawy HS, Tak PP. Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis. Ann Rheum Dis 2005; 64(5):715-721. abstract

Dik MG, Jonker C, Hack CE, Smit JH, Comijs HC, Eikelenboom P. Serum inflammatory proteins and cognitive decline in older persons. Neurology 2005; 64(8):1371-1377. abstract

Aalberse RC, Stapel SO. What can we learn from the ration of IgG1/IgG4 antibodies to allergens?. From Genes to Phenotypes : The basis of Future Allergy Management : Proc. of the 25th Symposium of the Collegium Internationale Allergologicum : Allergy & Clinical Immunology International - Journal of the World Allergy Organization, Supplement 2, 2005 2005; :190-192.

Bladergroen BA, Strik MC, Wolbink AM, Wouters D, Broekhuizen R, Kummer JA, Hack CE. The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells. Eur J Immunol 2005; 35(4):1175-1183. abstract

Familian A. Studies on pentraxin mediated complement activation. Free University of Amsterdam, Amsterdam, April 15, 2005;

Krijnen PA, Ciurana C, Cramer T, Hazes T, Meijer CJ, Visser CA, Niessen HW, Hack CE. IgM colocalises with complement and C reactive protein in infarcted human myocardium. J Clin Pathol 2005; 58(4):382-388. abstract

ten Brinke A, Dekkers DW, Notten SM, Karsten ML, de Groot ER, Aarden LA. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw 2005; 16(2):144-151. abstract

Wilcock LK, Wachholz PA, Hae-Won Na D, Aalberse RC, Larsen JN, Francis JN, Durham SR. Inhibition of IgE-Facilitated Allergen Presentation : A Longitudinal Study of Grass Pollen Immunotherapy. From Genes to Phenotypes : The basis of Future Allergy Management : Proc. of the 25th Symposium of the Collegium Internationale Allergologicum : Allergy & Clinical Immunology International - Journal of the World Allergy Organization, Supplement 2, 2005 2005; :244-247.

Leonard R, Petersen BO, Himly M, Kaar W, Wopfner N, Kolarich D, van Ree R, Ebner C, Duus JO, Ferreira F, Altmann F. Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding. J Biol Chem 2005; 280(9):7932-7940. abstract

Wahyuni S, Sartono E, Supali T, van der Zee JS, Mangali A, van Ree R, Houwing-Duistermaat JJ, Yazdanbakhsh M. Clustering of Allergic Outcomes within Families and Households in Areas Endemic for Helminth Infections. Int Arch Allergy Immunol 2005; 136(4):356-364. abstract

Strik MCM. The (patho-)physiological role of intracellular serine protease inhibitor. Free University (VU), Amsterdam, April 20, 2005;

van Mirre E. Novel insights in human Fcgamma-receptors and IgG : on genes, transcripts and functional interactions. University of Amsterdam (UvA), Amsterdam, October 20, 2005;

Wouters D, Wiessenberg HD, Hart M, Bruins P, Voskuyl A, Daha MR, Hack CE. Complexes between C1q and C3 or C4: novel and specific markers for classical complement pathway activation. J Immunol Methods 2005; 298(1-2):35-45. abstract

Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW, Kastelein JJ, Hack CE, Khaw KT. Serum Levels of Type II Secretory Phospholipase A2 and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women. The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol 2005; 25(4):839-846. abstract

Eysink PE, ter Riet G, Aalberse RC, van Aalderen WM, Roos CM, van der Zee JS, Bindels PJ. Accuracy of specific IgE in the prediction of asthma: development of a scoring formula for general practice. Br J Gen Pract 2005; 55(511):125-131. abstract

Fernandez-Rivas M, Brewczynski PZ, Kroon AM, van Ree R. A clinical trial with purified natural major allergens from grass pollen. Arbeiten aus dem Paul-Ehrlich-Institut ; Band 93; 9th International Paul-Ehrlich-Seminar 2000; :131-138.

Gilissen LJ, Bolhaar ST, Matos CI, Rouwendal GJ, Boone MJ, Krens FA, Zuidmeer L, van Leeuwen A, Akkerdaas J, Hoffmann-Sommergruber K, Knulst AC, Bosch D, van de Weg WE, van Ree R. Silencing the major apple allergen Mal d 1 by using the RNA interference approach. J Allergy Clin Immunol 2005; 115(2):364-369. abstract

Kerkhof M, Wijga A, Smit HA, de Jongste JC, Aalberse RC, Brunekreef B, Gerritsen J, Postma DS. The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study. Pediatr Allergy Immunol 2005; 16(1):10-18. abstract

van Oort E, Dieker MC, de Heer PG, Peltre G, Aalberse RC, van Ree R. The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split product both behave as dimers: implications for allergen standardization. Int Arch Allergy Immunol 2005; 136(2):113-122. abstract

van Ree R. A new start for allergen references and standardization based on purified (natural or recombinant) allergens and monoclonal and monospecific polyclonal antibodies. Arbeiten aus dem Paul-Ehrlich-Insititut ; Band 93; 9th International Paul-Ehrlich-Seminar 2000; :87-92.

Heaton T, Rowe J, Turner S, Aalberse RC, de Klerk N, Suriyaarachchi D, Serralha M, Holt BJ, Hollams E, Yerkovich S, Holt K, Sly PD, Goldblatt J, Le Souef P, Holt PG. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 2005; 365(9454):142-149. abstract

Nielen MM, van der Horst AR, van Schaardenburg D, Horst-Bruinsma IE, van de Stadt RJ, Aarden L, Dijkmans BA, Hamann D. Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis. Ann Rheum Dis 2005; 64 :1199-1204. abstract

Nielen MM, van der Horst AR, van Schaardenburg D, van der Horst-Bruinsma IE, van de Stadt RJ, Aarden L, Dijkmans BA, Hamann D. Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis. Ann Rheum Dis 2005; 64:1199-1204. abstract

Bolhaar ST, van Ree R, Ma Y, Bruijnzeel-Koomen CA, Vieths S, Hoffmann-Sommergruber K, Knulst AC, Zuidmeer L. Severe allergy to sharon fruit caused by birch pollen. Int Arch Allergy Immunol 2005; 136(1):45-52. abstract

Portielje JE, Kruit WH, Eerenberg AJ, Schuler M, Sparreboom A, Lamers CH, Gratama JW, Stoter G, Huber C, Hack CE. Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant. Cancer Immunol Immunother 2005; 54(1):37-43. abstract

Akkerdaas JH, Wensing M, Knulst AC, Stephan O, Hefle SL, Aalberse RC, van Ree R. A novel approach for the detection of potentially hazardous pepsin stable hazelnut proteins as contaminants in chocolate-based food. J Agric Food Chem 2004; 52(25):7726-7731. abstract

Mittag D, Akkerdaas J, Ballmer-Weber BK, Vogel L, Wensing M, Becker WM, Koppelman SJ, Knulst AC, Helbling A, Hefle SL, van Ree R, Vieths S. Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J Allergy Clin Immunol 2004; 114(6):1410-1417. abstract

Nijmeijer R, Krijnen PA, Assink J, Klaarenbeek MA, Lagrand WK, Veerhuis R, Visser CA, Meijer CJ, Niessen HW, Hack CE. C-reactive protein and complement depositions in human infarcted myocardium are more extensive in patients with reinfarction or upon treatment with reperfusion. Eur J Clin Invest 2004; 34(12):803-810. abstract

van Kuijk AW, de Groot M, Stapel SO, Dijkmans BA, Wolbink GJ, Tak PP. Relationship between the clinical response to adalimumab treatment and serum levels of adalimumab and anti-adalimumab antibodies in patients with psoriatic arthritis. Ann Rheum Dis 2010; 69(3):624-625. abstract

Bolhaar ST, van Ree R, Bruijnzeel-Koomen CA, Knulst AC, Zuidmeer L. Allergy to jackfruit: a novel example of Bet v 1-related food allergy. Allergy 2004; 59(11):1187-1192. abstract

Fernandez-Rivas M, Gonzalez-Mancebo E, van Leeuwen WA, Leon F, van Ree R. Anaphylaxis to raw carrot not linked to pollen allergy. Allergy 2004; 59(11):1239-1240. abstract

van Oort E, de Heer PG, Dieker M, van Leeuwen AW, Aalberse RC, van Ree R. Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens. J Allergy Clin Immunol 2004; 114(5):1124-1130. abstract

Wolbink GJ, Voskuyl A, Lems W, de Groot E, Nurmohamed MT, Tak PP, Dijkmans BA, Aarden L. Relation between serum trough infliximab levels, pre- treatment CRP levels and clinical response to infliximab treatment in rheumatoid arthritis. Ann Rheum Dis 2005; 64:704-707. abstract

van Ham SM, Samsom JN, Bos NA, Damoiseaux J, Laman JD, Wauben MH. Vaccination immunology: Prevention and beyond NVVI-Dutch society for immunology course Lunteren, 2008, April 3-4. Immunol Lett 2009; 2 (2):101-103. abstract

van Oort E, Lerouge P, de Heer PG, Seveno M, Coquet L, Modderman PW, Faye L, Aalberse RC, van Ree R. Substitution of Pichia pastoris-Derived Recombinant Proteins with Mannose Containing O- and N-Linked Glycans Decreases Specificity of Diagnostic Tests. Int Arch Allergy Immunol 2004; 135(3):187-195. abstract

de Lathouder S, Gerards AH, Dijkmans BA, Aarden LA. Two inhibitors of DNA-synthesis lead to inhibition of cytokine production via a different mechanism. Nucleosides Nucleotides Nucleic Acids 2004; 23(8-9):1089-1100. abstract

Diaz Padilla N, Ciurana C, van Oers J, Ogilvie AC, Hack CE. Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion. J Immunol Methods 2004; 293(1-2):1-11. abstract

Eysink PE, Bottema BJ, ter Riet G, Aalberse RC, Stapel SO, Bindels PJ. Coughing in pre-school children in general practice: when are RAST′s for inhalation allergy indicated?. Pediatr Allergy Immunol 2004; 15(5):394-400. abstract

Hack CE, Scheltens P. Intravenous immunoglobulins: a treatment for Alzheimer′s disease?. J Neurol Neurosurg Psychiatry 2004; 75(10):1374-1375. abstract

Johansson C, Tengvall Linder M, Aalberse RC, Scheynius A. Elevated levels of IgG and IgG4 to Malassezia allergens in atopic eczema patients with IgE reactivity to Malassezia. Int Arch Allergy Immunol 2004; 135(2):93-100. abstract

Kircher B, Hack CE, Dickinson AM, Wang XN, Oudshoorn M, Sachs A, Wolbink A, Niederwieser D, Eibl GJ, van Houwelingen HC, Goulmy E. Towards functional transplant donor matching by measurement of granzyme A and granzyme B production levels. J Immunol Methods 2004; 293(1-2):51-59. abstract

Padilla Diaz N, Ciurana C, van Oers J, Ogilvie AC, Hack CE. Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion. J Immunol Methods 2004; 293(1-2):1-11. abstract

Rowshani AT, Florquin S, Bemelman F, Kummer JA, Hack CE, ten Berge IJ. Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int 2004; 66(4):1417-1422. abstract

Boekholdt SM, Peters RJ, Day NE, Luben R, Bingham SA, Wareham NJ, Hack CE, Reitsma PH, Khaw KT. Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study. Am J Med 2004; 117(6):390-397. abstract

Teeling JL, French RR, Cragg MS, van den Brakel J, Pluyter M, Huang H, Chan C, Parren PW, Hack CE, Dechant M, Valerius T, van de Winkel JG, Glennie MJ. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 2004; 104(6):1793-1800. abstract

Agostoni A, Aygoren-Pursun E, Binkley KE, Blanch A, Bork K, Bouillet L, Bucher C, Castaldo AJ, Cicardi M, Davis AE, De Carolis C, Drouet C, Duponchel C, Farkas H, Fay K, Fekete B, Fischer B, Fontana L, Fust G, Giacomelli R, Groner A, Hack CE, Harmat G, Jakenfelds J, Juers M, Kalmar L, Kaposi PN, Karadi I, Kitzinger A, Kollar T, Kreuz W, Lakatos P, Longhurst HJ, Lopez-Trascasa M, Martinez-Saguer I, Monnier N, Nagy I, Nemeth E, Nielsen EW, Nuijens JH, O'grady C, Pappalardo E, Penna V, Perricone C, Perricone R, Rauch U, Roche O, Rusicke E, Spath PJ, Szendei G, Takacs E, Tordai A, Truedsson L, Varga L, Visy B, Williams K, Zanichelli A, Zingale L. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol 2004; 114(3 Suppl):S51-131. abstract

Ciurana CL, Zwart B, van Mierlo G, Hack CE. Complement activation by necrotic cells in normal plasma environment compares to that by late apoptotic cells and involves predominantly IgM. Eur J Immunol 2004; 34(9):2609-2619. abstract

de Jong NW, Groenewoud GC, van Ree R, van Leeuwen A, Vermeulen AM, van Toorenenbergen AW, de Groot H, van Wijk RG. Immunoblot and radioallergosorbent test inhibition studies of allergenic cross-reactivity of the predatory mite Amblyseius cucumeris with the house dust mite Dermatophagoides pteronyssinus. Ann Allergy Asthma Immunol 2004; 93(3):281-287. abstract

Mauad T, van Schadewijk A, Schrumpf J, Hack CE, Fernezlian S, Garippo AL, Ejzenberg B, Hiemstra PS, Rabe KF, Dolhnikoff M. Lymphocytic inflammation in childhood bronchiolitis obliterans. Pediatr Pulmonol 2004; 38(3):233-239. abstract

Tempels-Pavlica Z, Oosting AJ, Terreehorst I, van Wijk RG, Bruijnzeel-Koomen CA, de Monchy JG, Aalberse RC. Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust. Clin Exp Allergy 2004; 34(9):1444-1447. abstract

Chamuleau ME, Souwer Y, van Ham SM, Zevenbergen A, Westers TM, Berkhof J, Meijer CJ, van de Loosdrecht AA, Ossenkoppele GJ. Class II-associated invariant chain peptide expression on myeloid leukemic blasts predicts poor clinical outcome. Cancer Res 2004; 64(16):5546-5550. abstract

Aalberse RC, Stapel SO. Wanneer functioneert iets als allergeen?. Ned Tijdschr Allergie 2004; (juni-juli):84-90.

Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000; 122(1):20-32. abstract

de Lathouder S, Gerards AH, de Groot ER, Valkhof MG, Dijkmans BA, Aarden LA. Bioassay for detection of methotrexate in serum. Scand J Rheumatol 2004; 33(3):167-173. abstract

Hannema AJ, Hack CE. Complement en ontsteking. Ned Tijdschr Klin Chem Labgeneesk 2004; 28:145-150.

Matsui EC, Krop EJ, Diette GB, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse specific IgG and IgG4 levels. Ann Allergy Asthma Immunol 2004; 93(2):171-178. abstract

Muraro A, Dreborg S, Halken S, Host A, Niggemann B, Aalberse R, Arshad SH, von Berg A, Carlsen KH, Duschen K, Eigenmann P, Hill D, Jones C, Mellon M, Oldeus G, Oranje A, Pascual C, Prescott S, Sampson H, Svartengren M, Vandenplas Y, Wahn U, Warner JA, Warner JO, Wickman M, Zeiger RS. Dietary prevention of allergic diseases in infants and small children. Part III. Critical review of published peer-reviewed observational and interventional studies and final recommendations. Pediatr Allergy Immunol 2004; 15(4):291-307. abstract

van Mirre E, Teeling JL, van der Meer JW, Bleeker WK, Hack CE. Monomeric IgG in intravenous Ig preparations is a functional antagonist of FcgammaRII and FcgammaRIIIb. J Immunol 2004; 173(1):332-339. abstract

Boekholdt SM, Peters RJ, Hack CE, Day NE, Luben R, Bingham SA, Wareham NJ, Reitsma PH, Khaw KT. IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women. The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol 2004; 24(1503):1508. abstract

Baidoshvili A, Niessen HW, Stooker W, Huybregts RA, Hack CE, Rauwerda JA, Meijer CJ, Eijsman L, van Hinsbergh VW, Schalkwijk CG. N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels. Atherosclerosis 2004; 174(2):287-292. abstract

de Vroege R, van Oeveren W, van Klarenbosch J, Stooker W, Huybregts MA, Hack CE, van Barneveld L, Eijsman L, Wildevuur CR. The impact of heparin-coated cardiopulmonary bypass circuits on pulmonary function and the release of inflammatory mediators. Anesth Analg 2004; 98(6):1586-94, table. abstract

Muraro A, Dreborg S, Halken S, Host A, Niggemann B, Aalberse R, Arshad SH, von Berg A, Carlsen KH, Duschen K, Eigenmann P, Hill D, Jones C, Mellon M, Oldeus G, Oranje A, Pascual C, Prescott S, Sampson H, Svartengren M, Vandenplas Y, Wahn U, Warner JA, Warner JO, Wickman M, Zeiger RS. Dietary prevention of allergic diseases in infants and small children. Part II. Evaluation of methods in allergy prevention studies and sensitization markers. Definitions and diagnostic criteria of allergic diseases. Pediatr Allergy Immunol 2004; 15(3):196-205. abstract

van Ree R. The CREATE project: EU support for the improvement of allergen standardization in Europe. Allergy 2004; 59(6):571-574. abstract

van Ree R. Clinical importance of cross-reactivity in food allergy. Curr Opin Allergy Clin Immunol 2004; 4(3):235-240. abstract

Aalberse RC, Platts-Mills TA. How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective. J Allergy Clin Immunol 2004; 113(5):983-986. abstract

Bolhaar ST, Tiemessen MM, Zuidmeer L, van Leeuwen A, Hoffmann-Sommergruber K, Bruijnzeel-Koomen CA, Taams LS, Knol EF, Van Hoffen E, van Ree R, Knulst AC. Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. Clin Exp Allergy 2004; 34(5):761-769. abstract

Muraro A, Dreborg S, Halken S, Host A, Niggemann B, Aalberse R, Arshad SH, von Berg A, Carlsen K, Duschen K, Eigenmann P, Hill D, Jones C, Mellon M, Oldeus G, Oranje A, Pascual C, Prescott S, Sampson H, Svartengren M, Vandenplas Y, Wahn U, Warner JA, Warner JO, Wickman M, Zeiger RS. Dietary prevention of allergic diseases in infants and small children. Part I. Immunologic background and criteria for hypoallergenicity. Pediatr Allergy Immunol 2004; 15(2):103-111. abstract

Thomas K, Aalbers M, Bannon GA, Bartels M, Dearman RJ, Esdaile DJ, Fu TJ, Glatt CM, Hadfield N, Hatzos C, Hefle SL, Heylings JR, Goodman RE, Henry B, Herouet C, Holsapple M, Ladics GS, Landry TD, MacIntosh SC, Rice EA, Privalle LS, Steiner HY, Teshima R, van Ree R, Woolhiser M, Zawodny J. A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins. Regul Toxicol Pharmacol 2004; 39(2):87-98. abstract

de Lathouder S. Inhibition of Cytokine Production by Methotrexate : Studies in healthy volunteers and patients with rheumatoid arthritis. University of Amsterdam, Amsterdam, June 3, 2004;

Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, Wilcock LK, Staple SQ, Aalberse RC, Till SJ, Durham SR. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 2004; 172(5):3252-3259. abstract

Renckens R, Weijer S, de Vos AF, Pater JM, Meijers JC, Hack CE, Levi M, van der Poll T. Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia. Arterioscler Thromb Vasc Biol 2004; 24(3):483-488. abstract

van den Biggelaar AH, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YC, Souverijn JH, Missinou MA, Borrmann S, Kremsner PG, Yazdanbakhsh M. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 2004; 189(5):892-900. abstract

van Mirre E, van Royen A, Hack CE. IVIg-mediated amelioration of murine ITP via FcgammaRIIb is not necessarily independent of SHIP-1 and SHP-1 activity. Blood 2004; 103(5):1973. abstract

Zwart B, Ciurana C, Rensink I, Manoe R, Hack CE, Aarden LA. Complement activation by apoptotic cells occurs predominantly via IgM and is limited to late apoptotic (secondary necrotic) cells. Autoimmunity 2004; 37(2):95-102. abstract

Kummer JA, Strik MC, Bladergroen BA, Hack CE. Production, characterization, and use of serpin antibodies. Methods 2004; 32(2):141-149. abstract

Platts-Mills TA, Woodfolk JA, Erwin EA, Aalberse R. Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals. Springer Semin Immunopathol 2004; 25(3-4):271-279. abstract

Schocker F, Luttkopf D, Scheurer S, Petersen A, Cistero-Bahima A, Enrique E, Miguel-Moncin M, Akkerdaas J, van Ree R, Vieths S, Becker WM. Recombinant lipid transfer protein Cor a 8 from hazelnut: A new tool for in vitro diagnosis of potentially severe hazelnut allergy. J Allergy Clin Immunol 2004; 113(1):141-147. abstract

Biro E, Sturk-Maquelin KN, Vogel GM, Meuleman DG, Smit MJ, Hack CE, Sturk A, Nieuwland R. Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost 2003; 1(12):2561-2568. abstract

Tacx AN, Groeneveld AB, Hart MH, Aarden LA, Hack CE. Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation. J Clin Pathol 2003; 56(12):956-959. abstract

Aalberse RC, van Ree R. Monoclonal antibody assays for allergens: pick your antibodies with care!. J Allergy Clin Immunol 2000; 106(4):625-626. abstract

Branger J, van den Blink B, Weijer S, Gupta A, van Deventer SJH, Hack CE, Peppelenbosch MP, van der Poll T. Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. Blood 2003; 101(11):4446-4448. abstract

Cadot P, Kochuyt AM, van Ree R, Ceuppens JL. Oral allergy syndrome to chicory associated with birch pollen allergy. Int Arch Allergy Immunol 2003; 131(1):19-24. abstract

Hack CE. Derangements of coagulation and fibrinolysis in infectious diseases. Contrib Microbiol 2003; 10:18-37. abstract

Naldini A, Aarden L, Pucci A, Bernini C, Carraro F. Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses. Br J Pharmacol 2003; 140(5):980-986. abstract

Nijmeijer R, Willemsen M, Meijer CJ, Visser CA, Verheijen RH, Gottlieb RA, Hack CE, Niessen HW. Type II secretory phospholipase A2 binds to ischemic flip-flopped cardiomyocytes and subsequently induces cell death. Am J Physiol Heart Circ Physiol 2003; 285(5):H2218-H2224. abstract

Wahyuni S, van Ree R, Mangali A, Supali T, Yazdanbakhsh M, Sartono E. Comparison of an enzyme linked immunosorbent assay (ELISA) and a radioallergosorbent test (RAST) for detection of IgE antibodies to Brugia malayi. Parasite Immunol 2003; 25(11-12):609-614. abstract

Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol 2000; 106(2):228-238. abstract

Akkerdaas JH, Wensing M, Knulst AC, Krebitz M, Breiteneder H, de Vries S, Penninks AH, Aalberse RC, Hefle SL, van Ree R. How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents?. Int Arch Allergy Immunol 2003; 132(2):132-140. abstract

Kerkhof M, Koopman LP, van Strien RT, Wijga A, Smit HA, Aalberse RC, Neijens HJ, Brunekreef B, Postma DS, Gerritsen J. Risk factors for atopic dermatitis in infants at high risk of allergy: the PIAMA study. Clin Exp Allergy 2003; 33(10):1336-1341. abstract

Kleine Budde I, Aalberse RC. Histamine-releasing factors, a heterogeneous group of different activities. Clin Exp Allergy 2003; 33(9):1175-1182. abstract

Sturk-Maquelin KN, Nieuwland R, Romijn FP, Eijsman L, Hack CE, Sturk A. Pro- and non-coagulant forms of non-cell-bound tissue factor in vivo. J Thromb Haemost 2003; 1(9):1920-1926. abstract

Bos IG, Lubbers YT, Roem D, Abrahams JP, Hack CE, Eldering E. The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant. J Biol Chem 2003; 278(32):29463-29470. abstract

Aarden L. Immunologische overeenkomsten en verschillen tussen TNF-blokkers. Reumatologie Actueel 2003; 3(5)

Aarden L. Immunologische overeenkomsten en verschillen tussen TNF-blokkers. Gastro Actueel 2003; 7(13 desember)

Branger J, van den Blink B, Weijer S, Gupta A, van Deventer SJH, Hack CE, Peppelenbosch MP, van der Poll T. Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. Blood 2003; 101(11):4446-4448. abstract

Cadot P, Kochuyt AM, van Ree R, Ceuppens JL. Oral allergy syndrome to chicory associated with birch pollen allergy. Int Arch Allergy Immunol 2003; 131(1):19-24. abstract

Diaz Padilla N, Bleeker WK, Lubbers Y, Rigter GMM, van Mierlo GJ, Daha MR, Hack CE. Rat C-reactive protein activates the autologous complement system. Immunology 2003; 109(4):564-571. abstract

Hack CE. Derangements of coagulation and fibrinolysis in infectious diseases. Contrib Microbiol 2003; 10:18-37. abstract

Hesselink DA, Aarden LA, Swaak AJ. Profiles of the acute-phase reactants C-reactive protein and ferritin related to the disease course of patients with systemic lupus erythematosus. Scand J Rheumatol 2003; 32(3):151-155. abstract

van Oort E. Pros and Cons of Natural and Recombinant Allergens. University of Amsterdam, Amsterdam, September 19, 2003;

Zeerleder S, Zrcher Zenklusen R, Hack CE, Wuillemin WA. Disseminated intravascular coagulation in meningococcal sepsis. Case 7. Hamostaseologie 2003; 23(3):125-130. abstract

Terreehorst I, Hak E, Oosting AJ, Tempels-Pavlica Z, de Monchy JG, Bruijnzeel-Koomen CA, Aalberse RC, Gerth van Wijk R. Evaluation of impermeable covers for bedding in patients with allergic rhinitis. N Engl J Med 2003; 349(3):237-246. abstract

Besselink GA, van Engelenburg FA, Ebbing IG, Hilarius PM, de Korte D, Verhoeven AJ. Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment. Vox Sang 2003; 85(1):25-30. abstract

Nijmeijer R, Lagrand WK, Lubbers YT, Visser CA, Meijer CJ, Niessen HW, Hack CE. C-reactive protein activates complement in infarcted human myocardium. Am J Pathol 2003; 163(1):269-275. abstract

Suharti C, van Gorp EC, Dolmans WM, Setiati TE, Hack CE, Djokomoeljanto R, van der Meer JW. Cytokine patterns during dengue shock syndrome. Eur Cytokine Netw 2003; 14(3):172-177. abstract

Zeerleder S, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Sulzer I, Hack CE, Wuillemin WA. Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis. Clin Diagn Lab Immunol 2003; 10(4):529-535. abstract

Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C, van Nieuwenhuijze AE, van Mierlo GJ, Eerenberg AJ, Lammle B, Hack CE. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med 2003; 31(7):1947-1951. abstract

Hermsen CC, Konijnenberg Y, Mulder L, Loe C, van Deuren M, van der Meer JWM, van Mierlo GJ, Eling WM, Hack CE, Sauerwein RW. Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections. Clin Exp Immunol 2003; 132(3):467-472. abstract

Aalberse RC. Autologous dust RAST : A neglected tool to detect idiopathic sources of allergens in the home. Clin Rev Allergy Immunol 2000; 18(3):301-309. abstract

Biezeveld MH, Kuipers IM, Geissler J, Lam J, Ottenkamp JJ, Hack CE, Kuijpers TW. Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease. Lancet 2003; 361(9365):1268-1270. abstract

Aarden L. Immunologische overeenkomsten en verschillen tussen TNF-blokkers. Reumatologie Actueel 2003; 3(5)

Aarden L. Immunologische overeenkomsten en verschillen tussen TNF-blokkers. Gastro Actueel 2003; 7(13 desember)

Beezhold DH, Hickey VL, Kostyal DA, Puhl H, Zuidmeer L, van Ree R, Sussman GL. Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein. Ann Allergy Asthma Immunol 2003; 90(4):439-445. abstract

van Strien RT, Koopman LP, Kerkhof M, Oldenwening M, de Jongste JC, Gerritsen J, Neijens HJ, Aalberse RC, Smit HA, Brunekreef B. Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy 2003; 33(4):490-495. abstract

Groeneveld AB, Tacx AN, Bossink AW, van Mierlo GJ, Hack CE. Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection. Clin Immunol 2003; 106(2):106-115. abstract

de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003; 10(1):133-139. abstract

Roos A, Bouwman LH, Munoz J, Zuiverloon T, Faber-Krol MC, Fallaux-van den Houten FC, Klar-Mohamad N, Hack CE, Tilanus MG, Daha MR. Functional characterization of the lectin pathway of complement in human serum. Mol Immunol 2003; 39(11):655-668. abstract

van Nieuwenhuijze AE, van Lopik T, Smeenk RJ, Aarden LA. Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus. Ann Rheum Dis 2003; 62(1):10-14. abstract

Kleine Budde I, Lopuhaa CE, de Heer PG, Langdon JM, MacDonald SM, van der Zee JS, Aalberse RC. Lack of correlation between bronchial late allergic reaction to Dermatophagoides pteronyssinus and in vitro immunoglobulin E reactivity to histamine-releasing factor derived from mononuclear cells. Ann Allergy Asthma Immunol 2002; 89(6):606-612. abstract

Mulder C, Schoonenboom SN, Wahlund LO, Scheltens P, van Kamp GJ, Veerhuis R, Hack CE, Blomberg M, Schutgens RB, Eikelenboom P. CSF markers related to pathogenetic mechanisms in Alzheimer′s disease. J Neural Transm 2002; 109(12):1491-1498. abstract

Asero R, Mistrello G, Roncarolo D, Amato S, Caldironi G, Barocci F, van Ree R. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002; 57(10):900-906. abstract

Berckmans RJ, Nieuwland R, Tak PP, Boing AN, Romijn FP, Kraan MC, Breedveld FC, Hack CE, Sturk A. Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. Arthritis Rheum 2002; 46(11):2857-2866. abstract

Bladergroen BA, Meijer CJLM, ten Berge RL, Hack CE, Muris JJF, Dukers DF, Chott A, Kazama Y, Oudejans JJ, van Berkum O, Kummer JA. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?. Blood 2002; 99(1):232-237. abstract

de Zwaan C, Kleine AH, Diris JHC, Glatz JFC, Wellens HJJ, Strengers PFW, Tissing M, Hack CE, Dieijen-Visser MP, Hermens WT. Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction. Eur Heart J 2002; 23(21):1670-1677. abstract

Diris JHC, Hermens WT, Hemker PW, Lagrand WK, Hack CE, Dieijen-Visser MP. Pharmacokinetics of Cl-inhibitor protein in patients with acute myocardial infarction. Clin Pharmacol Ther 2002; 72(5):498-504. abstract

Eysink PED, Bindels PJE, Stapel SO, Bottema B, van der Zee JS, Aalberse RC. Do levels of immunoglobulin G antibodies to foods predict the development of immunoglobulin E antibodies to cat, dog and/or mite?. Clin Exp Allergy 2002; 32(4):556-562. abstract

Gentry PR, Hack CE, Haber L, Maier A, Clewell HJ. An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion. Toxicol Sci 2002; 70(1):120-139. abstract

Ioan-Facsinay A, de Kimpe SJ, Hellwig SMM, van Lent PL, Hofhuis FMA, van Ojik HH, Sedlik C, da Silveira SA, Gerber J, de Jong YF, Roozendaal R, Aarden LA, van den Berg WB, Saito T, Mosser D, Amigorena S, Izui S, van Ommen GJB, van Vugt M, van de Winkel JGJ, Verbeek JS. Fc-gamma RI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 2002; 16(3):391-402. abstract

Jellema WT, Veerman DP, de Winter RJ, Wesseling KH, van Deventer SJH, Hack CE, van Lieshout JJ. In vivo interaction of endotoxin and recombinant bactericidal/permeability-increasing protein (rBPl(23)): Hemodynamic effects in a human endotoxemia model. J Lab Clin Med 2002; 140(4):228-235. abstract

Krijnen PA, Nijmeijer R, Meijer CJ, Visser CA, Hack CE, Niessen HW. Apoptosis in myocardial ischaemia and infarction. J Clin Pathol 2002; 55(11):801-811. abstract

van Ree R. Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases. Int Arch Allergy Immunol 2002; 129(3):189-197. abstract

van Ree R. Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem Soc Trans 2002; 30(Pt 6):910-913. abstract

Wopfner N, Willeroidee M, Hebenstreit D, van Ree R, Aalbers M, Briza P, Thalhamer J, Ebner C, Richter K, Ferreira F. Molecular and immunological characterization of profilin from mugwort pollen. Biol Chem 2002; 383(11):1779-1789. abstract

Kleine Budde I, de Heer PG, Natter S, Mahler V, van der Zee JS, Valenta R, Aalberse RC. Studies on the association between immunoglobulin E autoreactivity and immunoglobulin E-dependent histamine-releasing factors. Immunology 2002; 107(2):243-251. abstract

Kuijf ML, Kwekkeboom J, Kuijpers MA, Willems M, Zondervan PE, Niesters HG, Hop WC, Hack CE, Paavonen T, Hockerstedt K, Tilanus HW, Lautenschlager I, Metselaar HJ, Kuijf MM. Granzyme expression in fine-needle aspirates from liver allografts is increased during acute rejection. Liver Transpl 2002; 8(10):952-956. abstract

Bos IG, Hack CE, Abrahams JP. Structural and functional aspects of C1-inhibitor. Immunobiology 2002; 205(4-5):518-533. abstract

Gonzalez EM, Villalba M, Lombardero M, Aalbers M, van Ree R, Rodriguez R. Influence of the 3D-conformation, glycan component and microheterogeneity on the epitope structure of Ole e 1, the major olive allergen. Use of recombinant isoforms and specific monoclonal antibodies as immunological tools. Mol Immunol 2002; 39(1-2):93-101. abstract

Trombone AP, Tobias KR, Ferriani VP, Schuurman J, Aalberse RC, Smith AM, Chapman MD, Arruda LK. Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis. Clin Exp Allergy 2002; 32(9):1323-1328. abstract

Brunekreef B, Smit J, de Jongste J, Neijens H, Gerritsen J, Postma D, Aalberse R, Koopman L, Kerkhof M, Wilga A, van Strien R. The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results. Pediatr Allergy Immunol 2002; 13 Suppl 15:55-60. abstract

Eysink PED, Bindels PJE, Stapel SO, Bottema B, van der Zee JS, Aalberse RC. Do levels of immunoglobulin G antibodies to foods predict the development of immunoglobulin E antibodies to cat, dog and/or mite?. Clin Exp Allergy 2002; 32(4):556-562. abstract

Hack CA, Benner WH. A simple algorithm improves mass accuracy to 50-100 ppm for delayed extraction linear matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2002; 16(13):1304-1312. abstract

Hack CE. CRP and cardiovascular disease: linked by complement?. Neth J Med 2002; 60(7):297-298. abstract

Ioan-Facsinay A, de Kimpe SJ, Hellwig SMM, van Lent PL, Hofhuis FMA, van Ojik HH, Sedlik C, da Silveira SA, Gerber J, de Jong YF, Roozendaal R, Aarden LA, van den Berg WB, Saito T, Mosser D, Amigorena S, Izui S, van Ommen GJB, van Vugt M, van de Winkel JGJ, Verbeek JS. Fc-gamma RI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 2002; 16(3):391-402. abstract

Jellema WT, Veerman DP, de Winter RJ, Wesseling KH, van Deventer SJH, Hack CE, van Lieshout JJ. In vivo interaction of endotoxin and recombinant bactericidal/permeability-increasing protein (rBPl(23)): Hemodynamic effects in a human endotoxemia model. J Lab Clin Med 2002; 140(4):228-235. abstract

Lagrand WK, Nijmeijer R, Niessen HWM, Visser CA, Hermens WT, Hack CE. C-reactive protein as a pro-inflammatory mediator in cardiovascular disease by its ability to activate complement : Additional proof and hypothetical mechanisms. Neth Heart J 2002; 10(4):189-197.

Nauta AJ, Trouw LA, Daha MR, Tijsma O, Nieuwland R, Schwaeble WJ, Gingras AR, Mantovani A, Hack CE, Roos A. Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol 2002; 32(6):1726-1736. abstract

Niessen HWM, Krijnen PAJ, Visser CA, Meijer CJLM, Hack CE. Intercellular adhesion molecule-1 in the heart. Ann N Y Acad Sci 2002; (973):573-585. abstract

Nijmeijer R, Lagrand WK, Baidoshvili A, Lubbers YTP, Hermens WT, Meijer CJLM, Visser CA, Hack CE, Niessen HWM. Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans. Cardiovasc Res 2002; 53(1):138-146. abstract

Roos A, Ramwadhdoebe TH, Nauta AJ, Hack CE, Daha MR. Therapeutic inhibition of the early phase of complement activation. Immunobiology 2002; 205(4-5):595-609. abstract

Strik MC, Bladergroen BA, Wouters D, Kisiel W, Hooijberg JH, Verlaan AR, Hordijk PL, Schneider P, Hack CE, Kummer JA. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. J Histochem Cytochem 2002; 50(11):1443-1453. abstract

van Gorp EC, Setiati TE, Mairuhu AT, Suharti C, Cate HH, Dolmans WM, van der Meer JW, Hack CE, Brandjes DP. Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever. J Med Virol 2002; 67(4):549-554. abstract

van Ree R, Yazdanbakhsh M. Parallels between parasite infections and specific immunotherapy. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94 :260-266.

van Ree R. The CREATE project: A new beginning of allergen standardization based on mass units of major allergens. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94 :70-75.

van Ree R. Isoallergens: a clinically relevant phenomenon or just a product of cloning?. Clin Exp Allergy 2002; 32(7):975-978. abstract

Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, Bruijnzeel-Koomen C, Aalberse RC, Bast BJEG, Knulst AC, van Ree R. IgE to Bet v 1 and profilin: Cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol 2002; 110(3):435-442. abstract

Wensing M, Penninks AH, Hefle SL, Akkerdaas JH, van Ree R, Koppelman SJ, Bruijnzeel-Koomen C, Knulst AC. The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. Clin Exp Allergy 2002; 32(12):1757-1762. abstract

Yazdanbakhsh M, Kremsner PG, van Ree R. Immunology - Allergy, parasites, and the hygiene hypothesis. Science 2002; 296(5567):490-494. abstract

Bos IG, ten Berge IJ, Hack CE. Role of complement in graft rejection after organ transplantation. Transfus Med Rev 2002; 16(3):251-264. abstract

de Lathouder S, Gerards AH, de Groot ER, Valkhof M, Aarden LA. Mycophenolic acid and methotrexate inhibit lymphocyte cytokine production via different mechanisms. Eur Cytokine Netw 2002; 13(3):317-323. abstract

Helsper JP, Gilissen LJ, van Ree R, America AH, Cordewener JH, Bosch D. Quadrupole time-of-flight mass spectrometry: a method to study the actual expression of allergen isoforms identified by PCR cloning. J Allergy Clin Immunol 2002; 110(1):131-138. abstract

ten Berge RL, Meijer CJ, Dukers DF, Kummer JA, Bladergroen BA, Vos W, Hack CE, Ossenkoppele GJ, Oudejans JJ. Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood 2002; 99(12):4540-4546. abstract

Hack CE, Niessen HW. Cardiovascular secrets of secretory phospholipase A(2). Eur J Clin Invest 2002; 32(6):381-382. abstract

de Jong MH, Scharp-van der Linden VT, Aalberse R, Heymans HS, Brunekreef B. The effect of brief neonatal exposure to cows′ milk on atopic symptoms up to age 5. Arch Dis Child 2002; 86(5):365-369. abstract

Branger J, van den Blink B, Weijer S, Madwed J, Bos CL, Gupta A, Yong CL, Polmar SH, Olszyna DP, Hack CE, van Deventer SJ, Peppelenbosch MP, van der Poll T. Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J Immunol 2002; 168(8):4070-4077. abstract

Akkerdaas JH, Wensing M, Knulst AC, Aalberse RC, Hefle SL, van Ree R. In vitro and in vivo characterization of hazelnut skin prick test extracts. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94:87-95.

Labrijn AF, Koppelman MH, Verhagen J, Brouwer MC, Schuitemaker H, Hack CE, Huisman HG. Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library. J Immunol Methods 2002; 261(1-2):37-48. abstract

van Ree R, Yazdanbakhsh M. Parallels between parasite infections and specific immunotherapy. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94:260-266.

van Ree R. The CREATE project: A new beginning of allergen standardization based on mass units of major allergens. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94:70-75.

Wisselink MA, van Ree R, Willemse T. Evaluation of Felis domesticus allergen I as a possible autoallergen in cats with eosinophilic granuloma complex. Am J Vet Res 2002; 63(3):338-341. abstract

Baidoshvili A, Nijmeijer R, Lagrand WK, Hack CE, Niessen HW. Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis. J Clin Pathol 2002; 55(2):152-153. abstract

Aalberse RC, Schuurman J. IgG4 breaking the rules. Immunology 2002; 105(1):9-19. abstract

Suharti C, van Gorp ECM, Setiati TE, Dolmans WM, Djokomoeljanto RJ, Hack CE, ten Cate H, van der Meer JWM. The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome. Thromb Haemost 2002; 87(1):42-46. abstract

van Oort E, de Heer PG, van Leeuwen WA, Derksen NI, Muller M, Huveneers S, Aalberse RC, van Ree R. Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite. Eur J Biochem 2002; 269(2):671-679. abstract

van Woensel JB, Biezeveld MH, Alders AM, Eerenberg AJ, Endert E, Hack CE, von Rosenstiel IA, Kuijpers TW. Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease. J Infect Dis 2001; 184(12):1532-1537. abstract

Hack CE. Fibrinolysis in disseminated intravascular coagulation. Semin Thromb Hemost 2001; 27(6):633-638. abstract

Kleine Budde I, de Heer PG, van der Zee JS, Aalberse RC. The stripped basophil histamine release bioassay as a tool for the detection of allergen-specific IgE in serum. Int Arch Allergy Immunol 2001; 126(4):277-285. abstract

Koraka P, Suharti C, Setiati TE, Mairuhu AT, van Gorp E, Hack CE, Juffrie M, Sutaryo J, van der Meer GM, Groen J, Osterhaus AD. Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol 2001; 39(12):4332-4338. abstract

Bleeker WK, Teeling JL, Hack CE. Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect. Blood 2001; 98(10):3136-3142. abstract

Aalberse RC, Kleine Budde I, Stapel SO, van Ree R. Structural aspects of cross-reactivity and its relation to antibody affinity. Allergy 2001; 56 Suppl 67:27-29. abstract

Aalberse RC, Stapel SO. Allergische reacties. Het allergie formularium : een praktische leidraad 2001; 2nd.:15-24.

Aalberse RC, Stapel SO. Structure of food allergens in relation to allergenicity. Pediatr Allergy Immunol 2001; 12 Suppl 14:10-14. abstract

Groeneveld AB, Bossink AW, van Mierlo GJ, Hack CE. Circulating inflammatory mediators in patients with fever: predicting bloodstream infection. Clin Diagn Lab Immunol 2001; 8(6):1189-1195. abstract

Kleine Budde I, de Heer PG, Stapel SO, van der Zee JS, Aalberse RC. Inadvertent BSA-induced elution of IgE in the BSA-RAST. Allergy 2001; 56(11):1055-1060. abstract

Ribeiro-do-Couto LM, Boeije LC, Kroon JS, Hooibrink B, Breur-Vriesendorp BS, Aarden LA, Boog CJ. High IL-13 production by human neonatal T cells: neonate immune system regulator?. Eur J Immunol 2001; 31(11):3394-3402. abstract

van Oort E, de Heer PG, Lerouge P, Faye L, Aalberse RC, van Ree R. Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens. Int Arch Allergy Immunol 2001; 126(3):196-205. abstract

Gruber C, Lau S, Dannemann A, Sommerfeld C, Wahn U, Aalberse RC. Down-regulation of IgE and IgG4 antibodies to tetanus toxoid and diphtheria toxoid by covaccination with cellular Bordetella pertussis vaccine. J Immunol 2001; 167(4):2411-2417. abstract

Teeling JL, Jansen-Hendriks T, Kuijpers TW, de Haas M, van de Winkel JG, Hack CE, Bleeker WK. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Blood 2001; 98(4):1095-1099. abstract

Aalberse RC, Kleine Budde I, Stapel SO, van Ree R. Structural aspects of cross-reactivity and its relation to antibody affinity. Allergy 2001; 56 Suppl 67:27-29. abstract

Aalberse RC, Stapel SO. Allergische reacties. Het allergie formularium : een praktische leidraad 2001; 2nd.:15-24.

Bos IG, van Mierlo GJ, Bleeker WK, Rigter GM, te Velthuis H, Dickneite G, Hack CE. The potentiation of human C1-inhibitor by dextran sulphate is transient in vivo: studies in a rat model. Int Immunopharmacol 2001; 1(8):1583-1595. abstract

Hack CE, Aarden LA. Immunopathologie. Interne geneeskunde ; 12 ed 2001; (5):81-109.

Killestein J, den Drijver BF, van der Graaff WL, Uitdehaag BMJ, Polman CH, van Lier RAW. Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease. Multiple Sclerosis 2001; 7(3):145-150. abstract

Lagrand WK, Niessen HWM, Nijmeijer R, Hack C. Role for complement as an intermediate between C-reactive protein and intercellular adhesion molecule-1 expression?. Circulation 2001; 104(9):E46-E46. abstract

Teeling JL, Bleeker WK, Hack CE, Kuijpers TW. Nieuwe inzichten in het ontstaan van bijwerkingen van intraveneuze immunoglobuline (IVIG)-preparaten. Ned Tijdschr Allergie 2001; 1:20-25.

Teeling JL. Interaction of intravenous immunoglobulins (IVIG) with Fc-receptors : activation and inhibition of phagocyte functions. University of Amsterdam, Amsterdam, October 17, 2001;

van der Kolk LE, Grillo-Lopez AJ, Baars JW, Hack CE, van Oers MHJ. Complement activation plays a key role in the side-effects of rituximab treatment. Br J Haematol 2001; 115(4):807-811.

Zeerleder S, Hack CE, Caliezi C, Hebeisen R, Wuillemin WA. Bacillus Calmette-Guerin sepsis: shift of an intended local toward a detrimental systemic cytotoxic immune response. Blood 2001; 98(3):890-891. abstract

Familian A, Zwart B, Huisman HG, Rensink I, Roem D, Hordijk PL, Aarden LA, Hack CE. Chromatin-independent binding of serum amyloid P component to apoptotic cells. J Immunol 2001; 167(2):647-654. abstract

Duchosal MA, Mauray S, Ruegg M, Trouillet P, Vallet V, Aarden L, Tissot JD, Schapira M. Human peripheral blood leukocyte engraftment into SCID mice: critical role of CD4(+) T cells. Cell Immunol 2001; 211(1):8-20. abstract

Asero R, Mistrello G, Roncarolo D, Amato S, van Ree R. A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Ann Allergy Asthma Immunol 2001; 87(1):65-67. abstract

Hack CE, Zeerleder S. The endothelium in sepsis: source of and a target for inflammation. Crit Care Med 2001; 29(7 Suppl):S21-S27. abstract

Juffrie M, Meer GM, Hack CE, Haasnoot K, Sutaryo, Veerman AJ, Thijs LG. Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2. Am J Trop Med Hyg 2001; 65(1):70-75. abstract

de Jonge E, Dekkers PE, Creasey AA, Hack CE, Paulson SK, Karim A, Kesecioglu J, Levi M, van Deventer SJ, van der Poll T. Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia. J Infect Dis 2001; 183(12):1815-1818. abstract

Aalberse RC, Akkerdaas J, van Ree R. Cross-reactivity of IgE antibodies to allergens. Allergy 2001; 56(6):478-490. abstract

Cugno M, Bos I, Lubbers Y, Hack CE, Agostoni A. In vitro interaction of C1-inhibitor with thrombin. Blood Coagul Fibrinolysis 2001; 12(4):253-260. abstract

Eysink P, Bindels P, Huisman J, Bottema B, Aalberse R, Schade B. Development of specific immunoglobulin E in coughing toddlers: a medical records review of symptoms in general practice. Pediatr Allergy Immunol 2001; 12(3):133-141. abstract

Joop K, Berckmans RJ, Nieuwland R, Berkhout J, Romijn FP, Hack CE, Sturk A. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost 2001; 85(5):810-820. abstract

Juffermans NP, Verbon A, Schultz MJ, Hack CE, van Deventer SJ, Speelman P, van der Poll T. Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens. Antimicrob Agents Chemother 2001; 45(5):1547-1549. abstract

Molenaar ET, Voskuyl AE, Familian A, van Mierlo GJ, Dijkmans BA, Hack CE. Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein. Arthritis Rheum 2001; 44(5):997-1002. abstract

van der Veen MJ, Jansen HM, Aalberse RC, van der Zee JS. Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response. Clin Exp Allergy 2001; 31(5):705-714. abstract

Berckmans RJ, Neiuwland R, Boing AN, Romijn FP, Hack CE, Sturk A. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 2001; 85(4):639-646. abstract

Meijer C, Wiezer MJ, Hack CE, Boelens PG, Wedel NI, Meijer S, Nijveldt RJ, Statius Muller MG, Wiggers T, Zoetmulder FA, Rinkes IH, Cuesta MA, Gouma DJ, van de Velde CJ, Tilanus HW, Scotte M, Thijs LG, van Leeuwen PA. Coagulopathy following major liver resection: the effect of rBPI21 and the role of decreased synthesis of regulating proteins by the liver. Shock 2001; 15(4):261-271. abstract

van Gorp EC, Minnema MC, Suharti C, Mairuhu AT, Brandjes DP, ten Cate H, Hack CE, Meijers JC. Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever. Br J Haematol 2001; 113(1):94-99. abstract

Bladergroen BA, Strik MC, Bovenschen N, van Berkum O, Scheffer GL, Meijer CJ, Hack CE, Kummer JA. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol 2001; 166(5):3218-3225. abstract

Mellembakken JR, Hogasen K, Mollnes TE, Hack CE, Abyholm T, Videm V. Increased systemic activation of neutrophils but not complement in preeclampsia. Obstet Gynecol 2001; 97(3):371-374. abstract

Nijmeijer R, Lagrand WK, Visser CA, Meijer CJ, Niessen HW, Hack CE. CRP, a major culprit in complement-mediated tissue damage in acute myocardial infarction?. Int Immunopharmacol 2001; 1(3):403-414. abstract

Teeling JL, Bleeker WK, Rigter GM, van Rooijen N, Kuijpers TW, Hack CE. Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model. Br J Haematol 2001; 112(4):1031-1040. abstract

van der Linden MW, van Lopik T, Aarden LA, Westendorp RG, Huizinga TW. Soluble CD95 concentrations are increased in patients with severe systemic lupus erythematosus, but not in their first degree relatives. Ann Rheum Dis 2001; 60(3):237-241. abstract

Verbon A, Dekkers PE, ten Hove T, Hack CE, Pribble JP, Turner T, Souza S, Axtelle T, Hoek FJ, van Deventer SJ, van der Poll T. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J Immunol 2001; 166(5):3599-3605. abstract

Portielje JE, Kruit WH, Eerenberg AJ, Schuler M, Sparreboom A, Lamers CH, Bolhuis RL, Stoter G, Huber C, Hack C. Interleukin 12 induces activation of fibrinolysis and coagulation in humans. Br J Haematol 2001; 112(2):499-505. abstract

Taylor FB, Haddad PA, Hack E, Chang AC, Peer GT, Morrissey JH, Li A, Allen RC, Wada H, Kinasewitz GT. Two-stage response to endotoxin infusion into normal human subjects: Correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response. Crit Care Med 2001; 29(2):326-334. abstract

Aalberse RC, Vermeulen E. Immune reactivity to mite allergens in nonatopic subjects: immune deviation or immune ignorance. Int Arch Allergy Immunol 2001; 124(1-3):208-209. abstract

Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2001; 124(1-3):67-69. abstract

Ronday HK, van der Laan WH, Tak PP, de Roos JA, Bank RA, te Koppele JM, Froelich CJ, Hack CE, Hogendoorn PC, Breedveld FC, Verheijen JH. Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. Rheumatology (Oxford) 2001; 40(1):55-61. abstract

Schuurman J, Perdok GJ, Gorter AD, Aalberse RC. The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds. Mol Immunol 2001; 38(1):1-8. abstract

Bruins P, te Velthuis H, Eerenberg-Belmer AJM, Yazdanbakhsh AP, de Beaumont EMFH, Eijsman L, Trouwborst A, Hack CE. Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: Studies in patients undergoing cardiac surgery and in vitro. Thromb Haemost 2000; 84(2):237-243. abstract

Citarella F, te Velthuis H, Helmer-Citterich M, Hack CE. Identification of a putative binding site for negatively charged surfaces in the fibronectin type II domain of human factor XII - An immunochemical and homology modeling approach. Thromb Haemost 2000; 84(6):1057-1065. abstract

Kleine Budde I, Aalbers M, Aalberse RC, van der Zee JS, Knol EF. Reactivity to IgE-dependent histamine-releasing factor is due to monomeric IgE. Allergy 2000; 55(7):653-657. abstract

Niessen HW, Lagrand WK, Rensink HJ, Meijer CJ, Aarden L, Hack CE. Apolipoprotein H, a new mediator in the inflammatory changes ensuring in jeopardised human myocardium. J Clin Pathol 2000; 53(11):863-867. abstract

Schultz MJ, Speelman P, Zaat SA, Hack CE, van Deventer SJ, van der Poll T. The effect of pseudomonas exotoxin A on cytokine production in whole blood exposed to Pseudomonas aeruginosa. FEMS Immunol Med Microbiol 2000; 29(3):227-232. abstract

Tremblay GM, Wolbink AM, Cormier Y, Hack CE. Granzyme activity in the inflamed lung is not controlled by endogenous serine proteinase inhibitors. J Immunol 2000; 165(7):3966-3969. abstract

Aalberse RC. Specific IgE and IgG responses in atopic versus nonatopic subjects. Am J Respir Crit Care Med 2000; 162(3 Pt 2):S124-S127. abstract

Hack CE. Tissue factor pathway of coagulation in sepsis. Crit Care Med 2000; 28(9 Suppl):S25-S30. abstract

Lauw FN, Pajkrt D, Hack CE, Kurimoto M, van Deventer SJ, van der Poll T. Proinflammatory effects of IL-10 during human endotoxemia. J Immunol 2000; 165(5):2783-2789. abstract

Soulika AM, Khan MM, Hattori T, Bowen FW, Richardson BA, Hack CE, Sahu A, Edmunds LH, Lambris JD. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol 2000; 96(3):212-221. abstract

Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol 2000; 106(2):228-238. abstract

Bruins P, te Velthuis H, Eerenberg-Belmer AJM, Yazdanbakhsh AP, de Beaumont EMFH, Eijsman L, Trouwborst A, Hack CE. Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: Studies in patients undergoing cardiac surgery and in vitro. Thromb Haemost 2000; 84(2):237-243. abstract

Bruins P. Changes in the inflammatory response during and after cardiac surgery. University of Amsterdam, Amsterdam, November 22, 2000;

Citarella F, te Velthuis H, Helmer-Citterich M, Hack CE. Identification of a putative binding site for negatively charged surfaces in the fibronectin type II domain of human factor XII - An immunochemical and homology modeling approach. Thromb Haemost 2000; 84(6):1057-1065. abstract

Fernandez-Rivas M, Brewczynski PZ, Kroon AM, van Ree R. A clinical trial with purified natural major allergens from grass pollen. Arbeiten aus dem Paul-Ehrlich-Institut ; Band 93; 9th International Paul-Ehrlich-Seminar 2000; :131-138.

Hack CE. C1-inhibitor: antigenic and functional analysis. Methods Mol Biol 2000; 150:159-172. abstract

Hack CE. The regulation of C1 activation and its role in disease. Therapeutic interventions in the complement system 2000; (2):33-56.

Kleine Budde I, Aalbers M, Aalberse RC, van der Zee JS, Knol EF. Reactivity to IgE-dependent histamine-releasing factor is due to monomeric IgE. Allergy 2000; 55(7):653-657. abstract

Lagrand WK, Visser CA, Hack CE, Niessen HWM, Nijmeijer R. C-reactive protein and cardiovascular disease: linked by complement?. Nephrol Dial Transplant 2000; 15(10):1709-1709. abstract

Lagrand WK, Visser CA, Niessen HWM, Hack CE, Hermens WT, Verheugt FWA, Wolbink GJ. C-reactive protein as a clinical marker of risk - Response to Comment by Kaski et al... Circulation 2000; 102(9):E63-E64.

Nieuwland R, Berckmans RJ, McGregor S, Boing AN, Romijn FP, Westendorp RGJ, Hack CE, Sturk A. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood 2000; 95(3):930-935. abstract

Schultz MJ, Speelman P, Hack CE, Buurman WA, van Deventer SJ, van der Poll T. Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae. J Antimicrob Chemother 2000; 46(2):235-240. abstract

van Ree R. A new start for allergen references and standardization based on purified (natural or recombinant) allergens and monoclonal and monospecific polyclonal antibodies. Arbeiten aus dem Paul-Ehrlich-Insititut ; Band 93; 9th International Paul-Ehrlich-Seminar 2000; :87-92.

Lauw FN, Simpson AJ, Hack CE, Prins JM, Wolbink AM, van Deventer SJ, Chaowagul W, White NJ, van der Poll T. Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. J Infect Dis 2000; 182(1):206-213. abstract

Mauray S, Fuzzati-Armentero MT, Trouillet P, Ruegg M, Nicoloso G, Hart M, Aarden L, Schapira M, Duchosal MA. Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6. Eur J Immunol 2000; 30(7):2065-2073. abstract

van Ree R, Aalbers M, Kea O, de la Calle MFM, Sempere Ortells JM, Villalba M, Rodriguez R, Aalberse RC. A sensitive monoclonal antibody sandwich ELISA for the measurement of the major olive pollen allergen Ole e 1. Int Arch Allergy Immunol 2000; 122(3):224-228. abstract

Aalberse RC. Autologous dust RAST : A neglected tool to detect idiopathic sources of allergens in the home. Clin Rev Allergy Immunol 2000; 18(3):301-309. abstract

Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, Verbeek E, Mohammadi T, Knul-Brettlova V, Akkerdaas JH, Bulder I, Aalberse RC, van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000; 122(1):20-32. abstract

van Ree R, Cabanes-Macheteau M, Akkerdaas J, Milazzo JP, Loutelier-Bourhis C, Rayon C, Villalba M, Koppelman S, Aalberse R, Rodriguez R, Faye L, Lerouge P. Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J Biol Chem 2000; 275(15):11451-11458. abstract

Bleeker WK, Teeling JL, Verhoeven AJ, Rigter GM, Agterberg J, Tool AT, Koenderman AH, Kuijpers TW, Hack CE. Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. Blood 2000; 95(5):1856-1861. abstract

Caliezi C, Wuillemin WA, Zeerleder S, Redondo M, Eisele B, Hack CE. C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema. Pharmacol Rev 2000; 52(1):91-112. abstract

de Jonge E, Dekkers PE, Creasey AA, Hack CE, Paulson SK, Karim A, Kesecioglu J, Levi M, van Deventer SJ, van der Poll T. Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. Blood 2000; 95(4):1124-1129. abstract

Minnema MC, Chang AC, Jansen PM, Lubbers YT, Pratt BM, Whittaker BG, Taylor FB, Hack CE, Friedman B. Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. Blood 2000; 95(4):1117-1123. abstract

Spaeny-Dekking EH, Kamp AM, Froelich CJ, Hack CE. Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood 2000; 95(4):1465-1472. abstract

Juffrie M, van der Meer GM, Hack CE, Haasnoot K, Sutaryo, Veerman AJ, Thijs LG. Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation. Infect Immun 2000; 68(2):702-707. abstract

van Ree R. Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases. Int Arch Allergy Immunol 2002; 129(3):189-197. abstract

van Strien RT, Koopman LP, Kerkhof M, Spithoven J, de Jongste JC, Gerritsen J, Neijens HJ, Aalberse RC, Smit HA, Brunekreef B. Mite and pet allergen levels in homes of children born to allergic and nonallergic parents: the PIAMA study. Environ Health Perspect 2002; 110(11):A693-A698. abstract

Verbon A, Meijers JC, Spek CA, Hack CE, Pribble JP, Turner T, Dekkers PE, Axtelle T, Levi M, van Deventer SJ, Reitsma PH, van der Poll T. Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans. J Infect Dis 2003; 187(1):55-61. abstract

Boks MA, Zwaginga JJ, van Ham SM, ten Brinke A. An optimized CFSE-based T-cell suppression assay to evaluate the suppressive capacity of regulatory T-cells induced by human tolerogenic dendritic cells. Scand J Immunol 2010; 72(2):158-168. abstract

Niessen HW, Hack CE. C-reactive protein and the risk of cardiovascular mortality. Am J Med 2003; 114(3):241-242. abstract

van Luijn MM, Chamuleau ME, Thompson JA, Ostrand-Rosenberg S, Westers TM, Souwer Y, Ossenkoppele GJ, van Ham SM, van de Loosdrecht AA. CLIP down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T cell responses. Haematologica 2010; 95(3):485-493. abstract

van der Veen MJ, Jansen HM, Aalberse RC, van der Zee JS. Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response. Clin Exp Allergy 2001; 31(5):705-714. abstract

Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedren S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM. PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy. Arthritis Rheum 2010; 62(7):1849-1861. abstract

Kerkhof M, Wijga A, Smit HA, de Jongste JC, Aalberse RC, Brunekreef B, Gerritsen J, Postma DS. The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study. Pediatr Allergy Immunol 2005; 16(1):10-18. abstract

ten Brinke A, van Schijndel G, Visser R, de Gruijl TD, Zwaginga JJ, van Ham SM. Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8(+) cytotoxic T cells with high cytolytic potential. Cancer Immunol Immunother 2010; 59(8):1185-1195. abstract

Damoiseaux J, Tervaert JW, Derksen R, Hamann D, Hooijkaas H, Klasen I, Kallenberg C, Limburg P, Smeenk R. Autoantibody standardization in The Netherlands. Ann N Y Acad Sci 2009; 1173:10-14. abstract

Zwart B. Processing of apoptotic cells in health and systemic autoimmune disease. Amsterdam, University of Amsterdam, March 30, 2010; abstract

Govers-Riemslag JW, Smid M, Cooper JA, Bauer KA, Rosenberg RD, Hack CE, Hamulyak K, Spronk HM, Miller GJ, ten Cate H. The plasma kallikrein-kinin system and risk of cardiovascular disease in men. J Thromb Haemost 2007; 5(9):1896-1903. abstract

Krop EJ, van de Pol MA, Lutter R, Heederik DJ, Aalberse RC, van der Zee JS. Dynamics in cytokine responses during the development of occupational sensitization to rats. Allergy 2010; :epub. abstract

Rispens T, Himly M, Ooievaar-De Heer PO, Bleker TH, Aalberse RC. Traces of pFc′ in IVIG interact with human IgG Fc domains and counteract aggregation. Eur J Pharm Sci 2010; 40(1):62-68. abstract

van Luijn MM, van den Ancker W, Chamuleau ME, Ossenkoppele GJ, van Ham SM, van de Loosdrecht AA. Impaired antigen presentation in neoplasia: basic mechanisms and implications for acute myeloid leukemia. Immunotherapy 2010; 2(1):85-97. abstract

van Luijn MM, Chamuleau ME, Thompson JA, Ostrand-Rosenberg S, Westers TM, Souwer Y, Ossenkoppele GJ, van Ham SM, van de Loosdrecht AA. Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T-cell responses. Haematologica 2010; 95(3):485-493. abstract

van der Windt GJ, Schouten M, Zeerleder S, Florquin S, van der Poll T. CD44 is Protective During Hyperoxia-induced Lung Injury. Am J Respir Cell Mol Biol 2010; :epub. abstract

Tran L, Baars JW, Aarden L, Beijnen JH, Huitema AD. Pharmacokinetics of rituximab in patients with CD20 positive B-cell malignancies. Hum Antibodies 2010; 19(1):7-13. abstract

Haanen JB, Baars A, Gomez R, Weder P, Smits M, de Gruijl TD, von Blomberg BM, Bloemena E, Scheper RJ, van Ham SM, Pinedo HM, van den Eertwegh AJ. Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients. Cancer Immunol Immunother 2006; 55(4):451-458. abstract

Nauta AJ, Bottazzi B, Mantovani A, Salvatori G, Kishore U, Schwaeble WJ, Gingras AR, Tzima S, Vivanco F, Egido J, Tijsma O, Hack CE, Daha MR, Roos A. Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol 2003; 33(2):465-473. abstract

Verbon A, Dekkers PE, ten Hove T, Hack CE, Pribble JP, Turner T, Souza S, Axtelle T, Hoek FJ, van Deventer SJ, van der Poll T. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J Immunol 2001; 166(5):3599-3605. abstract

Bousquet J, Ansotegui IJ, van Ree R, Burney PG, Zuberbier T, van Cauwenberge P. European Union meets the challenge of the growing importance of allergy and asthma in Europe. Allergy 2004; 59(1):1-4. abstract

Fernandez-Rivas M, Gonzalez-Mancebo E, van Leeuwen WA, Leon F, van Ree R. Anaphylaxis to raw carrot not linked to pollen allergy. Allergy 2004; 59(11):1239-1240. abstract

Kleine Budde I, Lopuhaa CE, de Heer PG, Langdon JM, MacDonald SM, van der Zee JS, Aalberse RC. Lack of correlation between bronchial late allergic reaction to Dermatophagoides pteronyssinus and in vitro immunoglobulin E reactivity to histamine-releasing factor derived from mononuclear cells. Ann Allergy Asthma Immunol 2002; 89(6):606-612. abstract

Straatsburg IH, Boermeester MA, Wolbink GJ, van Gulik TM, Gouma DJ, Frederiks WM, Hack CE. Complement activation induced by ischemia-reperfusion in humans: a study in patients undergoing partial hepatectomy. J Hepatol 2000; 32(5):783-791. abstract

Johansson C, Tengvall Linder M, Aalberse RC, Scheynius A. Elevated levels of IgG and IgG4 to Malassezia allergens in atopic eczema patients with IgE reactivity to Malassezia. Int Arch Allergy Immunol 2004; 135(2):93-100. abstract

Juffermans NP, Verbon A, Schultz MJ, Hack CE, van Deventer SJ, Speelman P, van der Poll T. Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens. Antimicrob Agents Chemother 2001; 45(5):1547-1549. abstract

Teeling JL, French RR, Cragg MS, van den Brakel J, Pluyter M, Huang H, Chan C, Parren PW, Hack CE, Dechant M, Valerius T, van de Winkel JG, Glennie MJ. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 2004; 104(6):1793-1800. abstract

Bos IGA, de Bruin EC, Karuntu YA, Modderman PW, Eldering E, Hack CE. Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor. Biochim Biophys Acta 2003; 1648(1-2):75-83. abstract

Cugno M, Bos I, Lubbers Y, Hack CE, Agostoni A. In vitro interaction of C1-inhibitor with thrombin. Blood Coagul Fibrinolysis 2001; 12(4):253-260. abstract

van Baarsen LG, Bos WH, Rustenburg F, van der Pouw Kraan TC, Wolbink GJ, Dijkmans BA, van Schaardenburg D, Verweij CL. Gene expression profiling in autoantibody positive arthralgia patients predicts development of arthritis. Arthritis Rheum 2010; 62(3):694-704. abstract

Hazelzet JA, Hack CE, de Groot R. Coagulation Studies. Meningococcal Disease : Methods and Protocols 2001; :513-527.

Bos WH, Bartelds GM, Wolbink GJ, de Koning MH, van de Stadt RJ, van Schaardenburg D, Dijkmans BA, Nurmohamed MT. Differential response of the rheumatoid factor and anticitrullinated protein antibodies during adalimumab treatment in patients with rheumatoid arthritis. J Rheumatol 2008; 35(10):1972-1977. abstract

Bos WH, Wolbink GJ, Boers M, Tijhuis GJ, de Vries N, Horst-Bruinsma IE, Tak PP, van de Stadt R, van der Laken CJ, Dijkmans BA, van Schaardenburg D. Arthritis development in arthralgia patients is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study. Ann Rheum Dis 2010; 69 (3):490-494. abstract

Diepenhorst GM, van Ruler O, Besselink MG, van Santvoort HC, Wijnandts PR, Renooij W, Gouma DJ, Gooszen HG, Boermeester MA. Influence of prophylactic probiotics and selective decontaminaton on bacterial translocation in patients undergoing pancreatic surgery: A randomized controlled trial. Shock 2010; :epub. abstract

Gerards AH, de Lathouder S, de Groot ER, Dijkmans BA, Aarden LA. Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis. Rheumatology (Oxford) 2003; 42(10):1189-1196. abstract

Padilla Diaz N, Ciurana C, van Oers J, Ogilvie AC, Hack CE. Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion. J Immunol Methods 2004; 293(1-2):1-11. abstract

Rispens T, den Bleker TH, Aalberse RC. Hybrid IgG4/IgG4 Fc antibodies form upon ′Fab-arm′ exchange as demonstrated by SDS-PAGE or size-exclusion chromatography. Mol Immunol 2010; 47(7-8):1592-1594. abstract

van Ree R, Cabanes-Macheteau M, Akkerdaas J, Milazzo JP, Loutelier-Bourhis C, Rayon C, Villalba M, Koppelman S, Aalberse R, Rodriguez R, Faye L, Lerouge P. Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J Biol Chem 2000; 275(15):11451-11458. abstract

Bem RA, Bos AP, Bots M, Wolbink AM, van Ham SM, Medema JP, Lutter R, van Woensel JB. Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. Pediatr Res 2008; 63(6):650-655. abstract

Bladergroen BA, Meijer CJLM, ten Berge RL, Hack CE, Muris JJF, Dukers DF, Chott A, Kazama Y, Oudejans JJ, van Berkum O, Kummer JA. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?. Blood 2002; 99(1):232-237. abstract

Koraka P, Murgue B, Deparis X, Setiati TE, Suharti C, van Gorp EC, Hack CE, Osterhaus AD, Groen J. Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity. J Med Virol 2003; 70(1):91-98. abstract

Minnema MC, Peters RJ, de Winter R, Lubbers YP, Barzegar S, Bauer KA, Rosenberg RD, Hack CE, ten Cate H. Activation of clotting factors XI and IX in patients with acute myocardial infarction. Arterioscler Thromb Vasc Biol 2000; 20(11):2489-2493. abstract

Ter Weeme M, Vonk AB, Kupreishvili K, van Ham M, Zeerleder S, Wouters D, Stooker W, Eijsman L, van Hinsbergh VW, Krijnen PA, Niessen HW. Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation. Eur J Clin Invest 2010; 40(1):4-10. abstract

van Woensel JB, Biezeveld MH, Alders AM, Eerenberg AJ, Endert E, Hack CE, von Rosenstiel IA, Kuijpers TW. Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease. J Infect Dis 2001; 184(12):1532-1537. abstract

Moons AH, van der Zee PM, Bholasingh R, Sturk A, Hack CE, Meijers JC, Kamp O, Cornel JH, Peters RJ, de Winter RJ. The value of haemostatic markers in the triage of patients with chest pain presenting with a normal or non-diagnostic ECG. Heart 2005; 91(9):1215-1216. abstract

van der Kolk L. CD20 monoclonal antibody therapy for B-cell lymphoma. University of Amsterdam, Amsterdam, March 15, 2001;

Bos IG, Lubbers YT, Eldering E, Abrahams JP, Hack CE. Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor. Biochim Biophys Acta 2004; 1699(1-2):139-144. abstract

Lecluse LL, Driessen RJ, Spuls PI, de Jong EM, Stapel SO, van Doorn MB, Bos JD, Wolbink GJ. Extent and clinical consequences of antibody formation against adalimumab in patients with plaque psoriasis. Arch Dermatol 2010; 146(2):127-132. abstract

Caliezi C, Zeerleder S, Redondo M, Regli B, Rothen HU, Zurcher-Zenklusen R, Rieben R, Devay J, Hack CE, Lammle B, Wuillemin WA. C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction. Crit Care Med 2002; 30(8):1722-1728. abstract

Besselink GA, van Engelenburg FA, Ebbing IG, Hilarius PM, de Korte D, Verhoeven AJ. Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment. Vox Sang 2003; 85(1):25-30. abstract

de Zwaan C, Kleine AH, Diris JHC, Glatz JFC, Wellens HJJ, Strengers PFW, Tissing M, Hack CE, Dieijen-Visser MP, Hermens WT. Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction. Eur Heart J 2002; 23(21):1670-1677. abstract

van der Putten RF, te Velthuis H, Aarden LA, ten Cate H, Glatz JF, Hermens WT. High-affinity antibodies in a new immunoassay for plasma tissue factor: reduction in apparent intra-individual variation. Clin Chem Lab Med 2005; 43(12):1386-1391. abstract

Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res 2005; 118 (2 ):205-212. abstract

Diemel RV, Ter Hart HG, Derksen GJ, Koenderman AH, Aalberse RC. Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products. Transfusion 2005; 45(10):1601-1609. abstract

Oosting AJ, Bruin-Weller MS, Terreehorst I, Tempels-Pavlica Z, Aalberse RC, de Monchy JG, van Wijk RG, Bruijnzeel-Koomen CA. Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: the Dutch Mite Avoidance Study. J Allergy Clin Immunol 2002; 110(3):500-506. abstract

Goldbach-Mansky R, Suson S, Wesley R, Hack CE, El Gabalawy HS, Tak PP. Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis. Ann Rheum Dis 2005; 64(5):715-721. abstract

van den Biggelaar AHJ, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbakhsh M. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 2000; 356(9243):1723-1727. abstract

Labrijn AF. Neutralizing antibodies to the HIV-1 envelope glycoproteins. University of Amsterdam, Amsterdam, February 24, 2004;

Brunekreef B, van Strien R, Pronk A, Oldenwening M, de Jongste JC, Wijga A, Kerkhof M, Aalberse RC. La mano de DIOS...was the PIAMA intervention study intervened upon?. Allergy 2005; 60(8):1083-1086. abstract

de Kleijn ED, de Groot R, Hack CE, Mulder PG, Engl W, Moritz B, Joosten KF, Hazelzet JA. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study. Crit Care Med 2003; 31(6):1839-1847. abstract

Den Bleker T, Derksen N, de Heer P, Vermeulen E, Aalberse R, Rispens T. IgG4, een bijzonder immunoglobuline. Analyse 2008; 63(5):132-138.

Strik MC, Wolbink A, Wouters D, Bladergroen BA, Verlaan AR, van Houdt IS, Hijlkema S, Hack CE, Kummer JA. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood 2004; 103(7):2710-2717. abstract

Levi M, Choi G, Picavet C, Hack CE. Self-administration of C1-inhibitor concentrate in patients with hereditary or acquired angioedema caused by C1-inhibitor deficiency. J Allergy Clin Immunol 2006; 117(4):904-908. abstract

Diris JHC, Hermens WT, Hemker PW, Lagrand WK, Hack CE, Dieijen-Visser MP. Pharmacokinetics of Cl-inhibitor protein in patients with acute myocardial infarction. Clin Pharmacol Ther 2002; 72(5):498-504. abstract

Bos WH, Bartelds GM, Vis M, van der Horst AR, Wolbink GJ, van de Stadt R, van Schaardenburg D, Dijkmans BA, Lems WF, Nurmohamed MT, Aarden L, Hamann D. Preferential decrease of IgG4 anti-citrullinated protein antibodies during treatment with TNF blocking agents in patients with rheumatoid arthritis. Ann Rheum Dis 2008; 68 (4):558-563. abstract

Schultz MJ, Millo J, Levi M, Hack CE, Weverling GJ, Garrard CS, van der Poll T. Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia. Thorax 2004; 59(2):130-135. abstract

Sancho AI, van Ree R, van Leeuwen A, Meulenbroek BJ, van de Weg EW, Gilissen LJ, Puehringer H, Laimer M, Martinelli A, Zaccharini M, Vazquez-Cortes S, Fernandez-Rivas M, Hoffmann-Sommergruber K, Mills EN, Zuidmeer L. Measurement of lipid transfer protein in 88 apple cultivars. Int Arch Allergy Immunol 2008; 146(1):19-26. abstract

Kleine Budde I, de Heer PG, Natter S, Mahler V, van der Zee JS, Valenta R, Aalberse RC. Studies on the association between immunoglobulin E autoreactivity and immunoglobulin E-dependent histamine-releasing factors. Immunology 2002; 107(2):243-251. abstract

Akkerdaas JH, Wensing M, Asero R, Rivas MF, Knulst AC, Bolhaar S, Hefle SL, Aalberse RC, van Ree R. IgE Binding to Pepsin-Digested Food Extracts. Int Arch Allergy Immunol 2005; 138(3):203-208. abstract

Koopman LP, van Strien RT, Kerkhof M, Wijga A, Smit HA, de Jongste JC, Gerritsen J, Aalberse RC, Brunekreef B, Neijens HJ. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med 2002; 166(3):307-313. abstract

Sancho AI, Rigby NM, Zuidmeer L, Asero R, Mistrello G, Amato S, Gonzalez-Mancebo E, Fernandez-Rivas M, van Ree R, Mills EN. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3. Allergy 2005; 60(10):1262-1268. abstract

Akkerdaas JH, Wensing M, Knulst AC, Aalberse RC, Hefle SL, van Ree R. In vitro and in vivo characterization of hazelnut skin prick test extracts. Arbeiten aus dem Paul-Ehrlich-Institut, Band 94, 10th International Paul-Ehrlich-Seminar 2002; 94 :87-95.

de Vries MK, Brouwer E, Horst-Bruinsma IE, Spoorenberg A, Van Denderen JC, Jamnitski A, Nurmohamed MT, Dijkmans BA, Aarden LA, Wolbink GJ. Decreased clinical response to adalimumab in ankylosing spondylitis is associated with antibody formation. Ann Rheum Dis 2009; 68(11):1787-1788. abstract

Aalberse RC, Stapel SO. Structure of food allergens in relation to allergenicity. Pediatr Allergy Immunol 2001; 12 Suppl 14:10-14. abstract

Baidoshvili A, Niessen HW, Stooker W, Huybregts RA, Hack CE, Rauwerda JA, Meijer CJ, Eijsman L, van Hinsbergh VW, Schalkwijk CG. N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels. Atherosclerosis 2004; 174(2):287-292. abstract

Himly M, Jahn-Schmid B, Dedic A, Kelemen P, Wopfner N, Altmann F, van Ree R, Briza P, Richter K, Ebner C, Ferreira F. Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain. FASEB J 2003; 17(1):106-108. abstract

Mackus WJ, Frakking FN, Grummels A, Gamadia LE, De Bree GJ, Hamann D, van Lier RA, van Oers MH. Expansion of CMV-specific CD8+CD45RA+. Blood 2003; 102(3):1057-1063. abstract

Duchosal MA, Mauray S, Ruegg M, Trouillet P, Vallet V, Aarden L, Tissot JD, Schapira M. Human peripheral blood leukocyte engraftment into SCID mice: critical role of CD4(+) T cells. Cell Immunol 2001; 211(1):8-20. abstract

Ciurana CLF. Molcular mechanisms of complement activation [Thesis]. University of Amsterdam, Amsterdam, October 28, 2004;

de Vries MK, Wolbink GJ, Stapel SO, de Groot ER, Dijkmans BA, Aarden LA, Horst-Bruinsma IE. Inefficacy of infliximab in ankylosing spondylitis is correlated with antibody formation. Ann Rheum Dis 2007; 66(1):133-134. abstract

Aalberse RC, Vermeulen E. Immune reactivity to mite allergens in nonatopic subjects: immune deviation or immune ignorance. Int Arch Allergy Immunol 2001; 124(1-3):208-209. abstract

Asero R, Mistrello G, Roncarolo D, Amato S, Caldironi G, Barocci F, van Ree R. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002; 57(10):900-906. abstract

Baidoshvili A, Krijnen PA, Kupreishvili K, Ciurana C, Bleeker W, Nijmeijer R, Visser CA, Visser FC, Meijer CJ, Stooker W, Eijsman L, van Hinsbergh VW, Hack CE, Niessen HW, Schalkwijk CG. N{varepsilon}-(Carboxymethyl)lysine Depositions in Intramyocardial Blood Vessels in Human and Rat Acute Myocardial Infarction. A Predictor or Reflection of Infarction?. Arterioscler Thromb Vasc Biol 2006; 26 (11):2497-2503. abstract

Biezeveld MH. Genes and Protein in Kawasaki Disease. University of Amsterdam, Amsterdam, March 28, 2007;

Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B. Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1. J Immunol 2010; 184(5):2686-2692. abstract

van Ree R. The CREATE project: EU support for the improvement of allergen standardization in Europe. Allergy 2004; 59(6):571-574. abstract

de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003; 10(1):133-139. abstract

Stapel SO, Eysink PE, Vrieze J, Aalberse RC. IgE testing in capillary blood. Pediatr Allergy Immunol 2004; 15(3):230-233. abstract